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<p><i>Nongmangkha</i> is one of the several medicinal plants traditionally used by the Meitei community of Manipur, India, for treating respiratory and infectious diseases. However, taxonomic confusion exists among three commonly used species— <i>Phlogacanthus thyrsiformis</i>&#xa0;(Roxb. ex Hardw.) Mabb, <i>Phlogacanthus pubinervius</i>&#xa0;T. Anderson, and <i>Justicia adhatoda</i>&#xa0;L<i>.</i>—limiting their safe and effective utilization. Three chloroplast gene- <i>rbcl</i>, <i>rpoC1</i> and <i>trnH-psbA</i> were used as DNA barcodes to identify the plants then, the sequences obtained were used for secondary structure prediction in RNAfold web server to discriminate among the three plants. The HPTLC revealed chemical fingerprints of the studied species which helped in taxonomic authentication of plants, while GC–MS and FTIR analysis of the extracts showed presence of several bioactive compounds and functional groups of the compounds respectively. Elemental analysis using XRF detected 19 elements in <i>P. pubinervius</i> indicating higher chemical diversity, while <i>J. adhatoda</i> and <i>P. thyrsiformis</i> contained 15 elements each. The plant extracts examined demonstrated significant antimicrobial activity against <i>Staphylococcus epidermidis, Pseudomonas aeruginosa, Epidermophyton floccosum, and Fusarium oxysporum</i>. To further explore their potential, molecular docking studies were carried out using the key bioactive compounds, which revealed promising interactions with Metallo-β-lactamase—suggesting their potential as effective antimicrobial agents. To the best of our knowledge, this is the first report to provide comparative insights into the three studied samples at anatomical, chemical, and molecular levels, paving the way toward accurate identification.</p>

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Integrative taxonomic and phytopharmacological analysis of ethnobotanical Acanthaceae species from Manipur, India

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年5月15日

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  • Khuraijam Jyoti,
  • Lushita Phairembam,
  • Nameirakpam Rikesh Mangang,
  • Shimrata Sharma Laimayum,
  • Salam Shyamchandra Singh,
  • Hmingremhlua Sailo,
  • Laldinfeli Ralte,
  • Naorem Santa Singh,
  • Moirangthem Rakesh Singh,
  • Yengkhom Tunginba Singh

摘要

Nongmangkha is one of the several medicinal plants traditionally used by the Meitei community of Manipur, India, for treating respiratory and infectious diseases. However, taxonomic confusion exists among three commonly used species— Phlogacanthus thyrsiformis (Roxb. ex Hardw.) Mabb, Phlogacanthus pubinervius T. Anderson, and Justicia adhatoda L.—limiting their safe and effective utilization. Three chloroplast gene- rbcl, rpoC1 and trnH-psbA were used as DNA barcodes to identify the plants then, the sequences obtained were used for secondary structure prediction in RNAfold web server to discriminate among the three plants. The HPTLC revealed chemical fingerprints of the studied species which helped in taxonomic authentication of plants, while GC–MS and FTIR analysis of the extracts showed presence of several bioactive compounds and functional groups of the compounds respectively. Elemental analysis using XRF detected 19 elements in P. pubinervius indicating higher chemical diversity, while J. adhatoda and P. thyrsiformis contained 15 elements each. The plant extracts examined demonstrated significant antimicrobial activity against Staphylococcus epidermidis, Pseudomonas aeruginosa, Epidermophyton floccosum, and Fusarium oxysporum. To further explore their potential, molecular docking studies were carried out using the key bioactive compounds, which revealed promising interactions with Metallo-β-lactamase—suggesting their potential as effective antimicrobial agents. To the best of our knowledge, this is the first report to provide comparative insights into the three studied samples at anatomical, chemical, and molecular levels, paving the way toward accurate identification.