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<p>Surface wettability, measured via water contact angle (WCA) measurements, is an essential parameter in evaluating the characteristics of sensor surfaces in plasmonic biosensing, particularly in Kretschmann-based surface plasmon resonance (K-SPR). This study investigates plasma polymerized heptylamine (ppHA) coatings for enhancing Au K-SPR biosensors. The WCA results, ranging from 58° to 82°, confirm that a hydrophilic surface promotes biomolecule immobilization. The red shift of the SPR curve at 785&#xa0;nm wavelength yields a refractive index sensitivity of 60°/RIU, with a good correlation coefficient (R² = 0.7584) between plasma power and WCA. The findings demonstrate that Au-ppHA coatings successfully optimize wettability and sensitivity, thereby improving SPR biosensor performance. Furthermore, the developed biosensor was successfully functionalized for creatinine detection, a key biomarker for kidney waste. The sensor demonstrated a high sensitivity of 1.1918 °/mM, confirming that ppHA coatings are an effective platform for developing high-performance K-SPR biosensors for medical diagnostics.</p>

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Enhancing SPR biosensor performance for creatinine detection via plasma polymerized heptylamine coatings

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年3月30日

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  • Nur Akmar Jamil,
  • Muhammad Feidhul Hakim Fatah Yasin,
  • Ilmi Munirah Karim,
  • Nur Dina Mariha Mat Sidin,
  • Hanis Yasmin Sofian,
  • Kiki Chan,
  • Siti Nasuha Mustaffa,
  • Affa Rozana Abdul Rashid,
  • Syara Kassim,
  • P. Susthitha Menon

摘要

Surface wettability, measured via water contact angle (WCA) measurements, is an essential parameter in evaluating the characteristics of sensor surfaces in plasmonic biosensing, particularly in Kretschmann-based surface plasmon resonance (K-SPR). This study investigates plasma polymerized heptylamine (ppHA) coatings for enhancing Au K-SPR biosensors. The WCA results, ranging from 58° to 82°, confirm that a hydrophilic surface promotes biomolecule immobilization. The red shift of the SPR curve at 785 nm wavelength yields a refractive index sensitivity of 60°/RIU, with a good correlation coefficient (R² = 0.7584) between plasma power and WCA. The findings demonstrate that Au-ppHA coatings successfully optimize wettability and sensitivity, thereby improving SPR biosensor performance. Furthermore, the developed biosensor was successfully functionalized for creatinine detection, a key biomarker for kidney waste. The sensor demonstrated a high sensitivity of 1.1918 °/mM, confirming that ppHA coatings are an effective platform for developing high-performance K-SPR biosensors for medical diagnostics.