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<p>Metabolic dysfunction-associated steatotic liver disease (MASLD) comprises a spectrum of liver diseases from simple steatosis, metabolic dysfunction-associated steatohepatitis (MASH) which progresses to fibrosis and compensated cirrhosis. Worldwide, MASLD significantly contributes to the rising incidence of liver cancer. Lille is known about its predictors in Asian population and particularly among Vietnamese. We determined the predictors of MASLD in Vietnamese population using a hospital-based case-control study of 100 MASLD patients and 119 healthy controls. Unconditional logistic regression model was used to calculate odds ratios (ORs) and respective 95% confidence intervals (CIs) for MASLD in relation to potential predictors. Overall, body mass index (BMI) (OR<sub>&gt; 23 vs. ≤23&#xa0;kg/m2</sub>=1.93, 95% CI: 1.00-3.72), diabetes (OR = 4.46, 95% CI: 1.16–17.12); AST (OR<sub>≥40 vs. &lt;40</sub>=4.18, 95% CI: 1.54–11.33), GGT (OR<sub>≥55738 vs. &lt;55738</sub>=5.20, 95% CI: 2.39–11.33), and international normalized ratio (INR) (OR<sub>&gt; 1.0 vs. ≤1.0</sub>=2.18, 95% CI: 1.15–4.14) were the predictors for MASLD. Other important clinical factors, including cardiometabolic condition, platelet, ALT, albumin, cholesterol or triglyceride were not associated with risk of MASLD. Clinical factors, including BMI, diabetes, AST, GGT, and INR played important roles as predictors for MASLD in Vietnamese population. Our findings, for the first time, provided evidence for risk stratification and treatment management of MASLD in Vietnamese population.</p>

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Predictors of metabolic dysfunction-associated steatotic liver diseases (MASLD) in Vietnamese population

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年4月17日

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  • Anh Gia Pham,
  • An Vu-Khanh Le,
  • Yen Thi-Hai Pham,
  • Lanh Sy Nguyen,
  • Huong Lan Nguyen,
  • Nghia Chinh Quach,
  • Thau Manh Cao,
  • Hanh Thi Nguyen,
  • Xuan Thanh Thai,
  • Anh Tuan Luong,
  • Thuy Thi Pham,
  • Hai Duy Vu,
  • Hai Thi-Thanh Tran,
  • Lan Thi Le,
  • Hai Vu,
  • Giang Binh Tran,
  • Hung N. Luu

摘要

Metabolic dysfunction-associated steatotic liver disease (MASLD) comprises a spectrum of liver diseases from simple steatosis, metabolic dysfunction-associated steatohepatitis (MASH) which progresses to fibrosis and compensated cirrhosis. Worldwide, MASLD significantly contributes to the rising incidence of liver cancer. Lille is known about its predictors in Asian population and particularly among Vietnamese. We determined the predictors of MASLD in Vietnamese population using a hospital-based case-control study of 100 MASLD patients and 119 healthy controls. Unconditional logistic regression model was used to calculate odds ratios (ORs) and respective 95% confidence intervals (CIs) for MASLD in relation to potential predictors. Overall, body mass index (BMI) (OR> 23 vs. ≤23 kg/m2=1.93, 95% CI: 1.00-3.72), diabetes (OR = 4.46, 95% CI: 1.16–17.12); AST (OR≥40 vs. <40=4.18, 95% CI: 1.54–11.33), GGT (OR≥55738 vs. <55738=5.20, 95% CI: 2.39–11.33), and international normalized ratio (INR) (OR> 1.0 vs. ≤1.0=2.18, 95% CI: 1.15–4.14) were the predictors for MASLD. Other important clinical factors, including cardiometabolic condition, platelet, ALT, albumin, cholesterol or triglyceride were not associated with risk of MASLD. Clinical factors, including BMI, diabetes, AST, GGT, and INR played important roles as predictors for MASLD in Vietnamese population. Our findings, for the first time, provided evidence for risk stratification and treatment management of MASLD in Vietnamese population.