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<p>Eccentric exercise-induced muscle damage (EIMD) impairs muscle function and recovery. While omega-3 polyunsaturated fatty acid (n-3 PUFA) supplementation has shown promise in mitigating EIMD, the role of their oxidation products (oxylipins) remains unclear. This study investigated the effects of 8-week n-3 PUFA supplementation on muscle recovery and its relationship with blood oxylipin profiles after EIMD in healthy men. Eighteen participants were randomly assigned into two groups: OMEGA (<i>n</i> = 9 28.0 ± 2.5 y; 2.5&#xa0;g/d of DHA and 0.5&#xa0;g/d of EPA) and PLACEBO (<i>n</i> = 9 21.4 ± 0.6 y; maltodextrin). Participants performed one bout of 100 unilateral isokinetic eccentric maximal voluntary contractions of the knee extensor muscles before and after an 8-week supplementation period. N-3 PUFA supplementation augmented plasma EPA- and DHA-derived oxylipins (<i>p</i> &lt; 0.05) in the OMEGA group, which showed an attenuation of peak muscle maximum voluntary contraction loss (-15.4 ± 5.2%; <i>p</i> = 0.05) post-exercise compared to the PLACEBO group (1.3 ± 6.0%). There were no differences in muscles soreness between groups. Multivariate analyses identified body fat percentage and specific n-3 and n-6 PUFA-derived oxylipins as predictors of MVC loss after EIMD. In conclusion, the increased plasma levels of n-3 PUFA derived oxylipins following supplementation suggest a possible role for these lipid mediators in promoting muscle recovery.</p>

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Improved muscle recovery after omega-3 supplementation is associated with increased oxylipin availability

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年3月13日

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  • Claudia Miranda-Fuentes,
  • Carlos O. Rehbein,
  • Cristian Campos,
  • Yael Toporowicz,
  • Joseline Arredondo,
  • Sebastián Gutierrez,
  • Oscar Nuñez,
  • Sofia Uribe-Cerda,
  • Barbara Castillo,
  • Matías Diaz-León,
  • Delia Quintero-Soto,
  • Antonia Del Canto-Cruz,
  • Tanja Winter,
  • Camila Farías,
  • Bernardo J. Krause,
  • Rodrigo Valenzuela,
  • Harold M. Aukema,
  • Denisse Valladares-Ide,
  • Luis Peñailillo,
  • Sebastián Jannas-Vela

摘要

Eccentric exercise-induced muscle damage (EIMD) impairs muscle function and recovery. While omega-3 polyunsaturated fatty acid (n-3 PUFA) supplementation has shown promise in mitigating EIMD, the role of their oxidation products (oxylipins) remains unclear. This study investigated the effects of 8-week n-3 PUFA supplementation on muscle recovery and its relationship with blood oxylipin profiles after EIMD in healthy men. Eighteen participants were randomly assigned into two groups: OMEGA (n = 9 28.0 ± 2.5 y; 2.5 g/d of DHA and 0.5 g/d of EPA) and PLACEBO (n = 9 21.4 ± 0.6 y; maltodextrin). Participants performed one bout of 100 unilateral isokinetic eccentric maximal voluntary contractions of the knee extensor muscles before and after an 8-week supplementation period. N-3 PUFA supplementation augmented plasma EPA- and DHA-derived oxylipins (p < 0.05) in the OMEGA group, which showed an attenuation of peak muscle maximum voluntary contraction loss (-15.4 ± 5.2%; p = 0.05) post-exercise compared to the PLACEBO group (1.3 ± 6.0%). There were no differences in muscles soreness between groups. Multivariate analyses identified body fat percentage and specific n-3 and n-6 PUFA-derived oxylipins as predictors of MVC loss after EIMD. In conclusion, the increased plasma levels of n-3 PUFA derived oxylipins following supplementation suggest a possible role for these lipid mediators in promoting muscle recovery.