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<p>Spontaneous resolution represents an ideal therapeutic outcome for intervertebral disc herniation, a prevalent clinical disorder. Drawing on our prior cervical spine research, we have demonstrated that herniated disc tissue is absorbable, a process we term the induced resorption of herniated nucleus pulposus (iRHNP). We hypothesized that a synergistic microenvironment—combining mechanical force withdrawal (decompression) and the biological activity of bone healing (release of bioactive factors)—artificially drives iRHNP. This study employed integrated in vitro and in vivo models, including rat explant co-cultures and a rabbit laminoplasty model, to confirm disc volume reduction and associated matrix degradation. Based on this mechanistic insight, we developed a novel Resolution-Induction technique for Lumbar Disc Herniation (RI-LDH). A subsequent prospective clinical study verified the iRHNP phenomenon and its underlying mechanism. Our findings elucidate, for the first time, a synergistic “decompression + bone bioactive factors” mechanism. Patients treated with RI-LDH exhibited excellent clinical outcomes, correlating with symmetric spinal canal decompression, bony reconstruction, and significant iRHNP. This work establishes the foundation for a novel resolution-oriented therapeutic strategy for disc herniation.</p>

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Synergetic mechanism by decompression and bone bioactive factors to induce the spontaneous resolution of lumbar disc herniation

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年4月14日

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  • Yan Jiang,
  • Su Fu,
  • Xu Yan,
  • Chunlin Zhang

摘要

Spontaneous resolution represents an ideal therapeutic outcome for intervertebral disc herniation, a prevalent clinical disorder. Drawing on our prior cervical spine research, we have demonstrated that herniated disc tissue is absorbable, a process we term the induced resorption of herniated nucleus pulposus (iRHNP). We hypothesized that a synergistic microenvironment—combining mechanical force withdrawal (decompression) and the biological activity of bone healing (release of bioactive factors)—artificially drives iRHNP. This study employed integrated in vitro and in vivo models, including rat explant co-cultures and a rabbit laminoplasty model, to confirm disc volume reduction and associated matrix degradation. Based on this mechanistic insight, we developed a novel Resolution-Induction technique for Lumbar Disc Herniation (RI-LDH). A subsequent prospective clinical study verified the iRHNP phenomenon and its underlying mechanism. Our findings elucidate, for the first time, a synergistic “decompression + bone bioactive factors” mechanism. Patients treated with RI-LDH exhibited excellent clinical outcomes, correlating with symmetric spinal canal decompression, bony reconstruction, and significant iRHNP. This work establishes the foundation for a novel resolution-oriented therapeutic strategy for disc herniation.