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<p>Physical barriers presented by solid tumors limit CAR T cell efficacy. Thus, technologies to increase CAR T cell access to solid tumors could have massive implications in advancing CAR T cell therapies. Here we demonstrate that treatment of solid tumor-bearing mice with our Junction Opener technology and CAR T cells enhances tumor control - potentially enabling CAR T cell immunotherapy for solid tumors.</p>

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Junction opener enables CAR T cell treatment of solid tumors

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年3月7日

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  • Steven J. Reed,
  • Shibbu Sharma,
  • Carrie Novák,
  • Jiho Kim,
  • Kaman Kim,
  • Erene Niemi,
  • Nicholas Korjeff,
  • André Lieber,
  • Steven G. Reed,
  • Malcolm S. Duthie,
  • Darrick Carter

摘要

Physical barriers presented by solid tumors limit CAR T cell efficacy. Thus, technologies to increase CAR T cell access to solid tumors could have massive implications in advancing CAR T cell therapies. Here we demonstrate that treatment of solid tumor-bearing mice with our Junction Opener technology and CAR T cells enhances tumor control - potentially enabling CAR T cell immunotherapy for solid tumors.