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<p>Atorvastatin (ATV) is widely prescribed in Egypt, where cardiovascular disease remains the leading cause of mortality; however, it is prone to clinically significant drug–drug interactions (DDIs). This national cross-sectional study evaluated community pharmacists’ (CPs’) knowledge, practice behaviors, and reported rates of ATV-related DDIs across Egypt. A total of 973 licensed pharmacists completed a validated survey. The mean cumulative practice score was 7.2 ± 1.91, indicating high adherence to recommended safety practices. Frequently reported roles included targeting polypharmacy patients (80.1%), initiating single-drug therapy when appropriate (82.2%), counseling patients about adverse effects (85.1%), and using web-based drug-information resources (88.2%), whereas structured DDI screening tool use was less common (46.1%). Compared with male pharmacists, female pharmacists presented significantly higher cumulative practice scores (7.52 ± 1.59 vs. 7.08 ± 1.99; <i>p</i> = 0.016), and diploma holders scored higher than Ph.D. holders did (7.47 ± 1.81 vs. 6.82 ± 1.87; adjusted <i>p</i> = 0.02). High-frequency encounters were reported for major DDIs with cyclosporine (49.3%) and clarithromycin (45.8%) and for moderate DDIs with digoxin (42.2%), phenytoin (41.0%), and azithromycin (40.5%). Regional variation showed higher interaction frequencies in Upper Egypt and the Delta. Strengthening pharmacist stewardship programs and expanding standardized DDI screening approaches may improve ATV safety.</p>

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Nationwide assessment of community pharmacists’ practices and atorvastatin–drug interactions in Egypt

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年3月27日

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  • Mohammed G. Maslub,
  • Mahasen Ali Radwan,
  • Nur Aizati Athirah Daud,
  • Zeyad Ali Abd-Alla,
  • Marwa Adham El-Mohamdy

摘要

Atorvastatin (ATV) is widely prescribed in Egypt, where cardiovascular disease remains the leading cause of mortality; however, it is prone to clinically significant drug–drug interactions (DDIs). This national cross-sectional study evaluated community pharmacists’ (CPs’) knowledge, practice behaviors, and reported rates of ATV-related DDIs across Egypt. A total of 973 licensed pharmacists completed a validated survey. The mean cumulative practice score was 7.2 ± 1.91, indicating high adherence to recommended safety practices. Frequently reported roles included targeting polypharmacy patients (80.1%), initiating single-drug therapy when appropriate (82.2%), counseling patients about adverse effects (85.1%), and using web-based drug-information resources (88.2%), whereas structured DDI screening tool use was less common (46.1%). Compared with male pharmacists, female pharmacists presented significantly higher cumulative practice scores (7.52 ± 1.59 vs. 7.08 ± 1.99; p = 0.016), and diploma holders scored higher than Ph.D. holders did (7.47 ± 1.81 vs. 6.82 ± 1.87; adjusted p = 0.02). High-frequency encounters were reported for major DDIs with cyclosporine (49.3%) and clarithromycin (45.8%) and for moderate DDIs with digoxin (42.2%), phenytoin (41.0%), and azithromycin (40.5%). Regional variation showed higher interaction frequencies in Upper Egypt and the Delta. Strengthening pharmacist stewardship programs and expanding standardized DDI screening approaches may improve ATV safety.