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<p>This study aimed to clarify the relationship between periodontitis and non-alcoholic fatty liver disease (NAFLD). A survey was conducted with 2,453 participants who visited the dental clinic at the Asahi University Hospital. Periodontitis was evaluated using the Community Periodontal Index (CPI), and NAFLD was evaluated using multiple tools such as Fibrosis-4 (FIB4), NAFLD fibrosis score (NFS), and Fatty Liver Index (FLI). The relationship between periodontitis and the cutoff values of three NAFLD assessment tools by logistic regression analyses indicated that PPD ≥ 6&#xa0;mm was significantly associated with NFS &gt; 0.675 (OR = 4.11, 95%CI:1.06–15.99) and with FLI ≥ 60 (OR = 1.76, 95%CI:1.12–2.76). The participants with BOP positive indicated a significant association between PPD ≥ 6&#xa0;mm and FLI ≥ 60 (OR = 1.68, 95%CI:1.05–2.70). However, no association was found in participants without BOP. These results suggest that periodontal inflammation is associated with NAFLD, as assessed using the FLI.</p>

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Nonalcoholic fatty liver disease assessed by multiple tools are correlated to periodontal conditions

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年3月2日

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  • Takatoshi Hiroshimaya,
  • Komei Iwai,
  • Marika Marutani,
  • Tetsuji Azuma,
  • Takatoshi Yonenaga,
  • Koichiro Tabata,
  • Kazutoshi Watanabe,
  • Fumiko Deguchi,
  • Akihiro Obora,
  • Takao Kojima,
  • Takaaki Tomofuji,
  • Naofumi Tamaki

摘要

This study aimed to clarify the relationship between periodontitis and non-alcoholic fatty liver disease (NAFLD). A survey was conducted with 2,453 participants who visited the dental clinic at the Asahi University Hospital. Periodontitis was evaluated using the Community Periodontal Index (CPI), and NAFLD was evaluated using multiple tools such as Fibrosis-4 (FIB4), NAFLD fibrosis score (NFS), and Fatty Liver Index (FLI). The relationship between periodontitis and the cutoff values of three NAFLD assessment tools by logistic regression analyses indicated that PPD ≥ 6 mm was significantly associated with NFS > 0.675 (OR = 4.11, 95%CI:1.06–15.99) and with FLI ≥ 60 (OR = 1.76, 95%CI:1.12–2.76). The participants with BOP positive indicated a significant association between PPD ≥ 6 mm and FLI ≥ 60 (OR = 1.68, 95%CI:1.05–2.70). However, no association was found in participants without BOP. These results suggest that periodontal inflammation is associated with NAFLD, as assessed using the FLI.