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<p>Early bone formation around implants depends on both the chemical composition and the micro-, nanoscale architecture of the implant surface. Nanoscale modifications can accelerate osseointegration, and laser processing offers a versatile method of creating such features. In this study, titanium substrates were modified using a single-step nanosecond laser treatment at two energy regimes (1.95&#xa0;mJ/pulse for P_0.5; 4.00&#xa0;mJ/pulse for P_0.4). The resulting surfaces were characterized by SEM, EDS, XRD, Raman spectroscopy, ToF-SIMS, contact angle, and topography measurements, with biological assessment performed using a mouse preosteoblast cell line. Analyses revealed various titanium oxo clusters (TiO<sub>3</sub><sup>–</sup>, TiO<sub>2</sub><sup>–</sup>, TiO<sup>–</sup>) and moderate oxidation levels (25–31 at% O). Both laser regimes produced rough, hydrophobic surfaces. Cytotoxicity tests confirmed that the materials were non-toxic, and proliferation assays showed increasing preosteoblast numbers over time, indicating that both surfaces supported cell division. Good adhesion of preosteoblasts was observed on P_0.4 and P_0.5. This work demonstrates that nanosecond laser processing alone can generate micro-, nanostructured titanium implant surfaces with favourable biocompatibility, achieving performance comparable to more complex femtosecond methods while offering a cost-effective and scalable surface engineering strategy.</p>

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Single step nanosecond laser structuring for cost effective functional titanium surfaces with topography driven preosteoblast adhesion

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年2月3日

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  • Adriana Barylyak,
  • Sarunas Meskinis,
  • Algirdas Lazauskas,
  • Piotr Krzemiński,
  • Renata Wojnarowska-Nowak,
  • Małgorzata Trzyna-Sowa,
  • Marta Trzaskowska,
  • Vladyslav Vivcharenko,
  • Bogumił Cieniek,
  • Agata Przekora,
  • Andrzej Dziedzic,
  • Yaroslav Bobitski,
  • Joanna Kisała

摘要

Early bone formation around implants depends on both the chemical composition and the micro-, nanoscale architecture of the implant surface. Nanoscale modifications can accelerate osseointegration, and laser processing offers a versatile method of creating such features. In this study, titanium substrates were modified using a single-step nanosecond laser treatment at two energy regimes (1.95 mJ/pulse for P_0.5; 4.00 mJ/pulse for P_0.4). The resulting surfaces were characterized by SEM, EDS, XRD, Raman spectroscopy, ToF-SIMS, contact angle, and topography measurements, with biological assessment performed using a mouse preosteoblast cell line. Analyses revealed various titanium oxo clusters (TiO3–, TiO2–, TiO–) and moderate oxidation levels (25–31 at% O). Both laser regimes produced rough, hydrophobic surfaces. Cytotoxicity tests confirmed that the materials were non-toxic, and proliferation assays showed increasing preosteoblast numbers over time, indicating that both surfaces supported cell division. Good adhesion of preosteoblasts was observed on P_0.4 and P_0.5. This work demonstrates that nanosecond laser processing alone can generate micro-, nanostructured titanium implant surfaces with favourable biocompatibility, achieving performance comparable to more complex femtosecond methods while offering a cost-effective and scalable surface engineering strategy.