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<p>To evaluate the potential value of combining contrast-enhanced ultrasound (CEUS) with shear wave elastography (SWE) for predicting pathological complete response (pCR) in patients with breast cancer receiving neoadjuvant chemotherapy (NAC). Ultrasound (US), CEUS and SWE examinations were performed before and after NAC. The maximum tumor diameter on US (D<sub>US</sub>) and CEUS (D<sub>CEUS</sub>), the maximum stiffness of SWE (Emax), their changes and consistency with the postoperative pathological analysis were evaluated, and their predictive value was compared using the receiver operating characteristic (ROC) curve. 60 patients were included among whom 28 (46.7%) achieved pCR and 32 (53.3%) exhibited non-pCR. The changes in D<sub>CEUS</sub> and Emax were significantly correlated with pCR (<i>p</i> &lt; 0.005). ΔD<sub>CEUS</sub>% differed significantly between pCR and non-pCR groups across all molecular subtypes. However, ΔEmax% differed significantly in ER negative, PR negative and Her-2 negative breast cancer after NAC. The combination of ΔD<sub>CEUS</sub>% and ΔEmax% demonstrated superior predictive ability for NAC response, with an area under the curve (AUC) of 0.906, outperforming ΔD<sub>CEUS</sub>% (AUC 0.871) or ΔEmax% (AUC 0.722) alone. CEUS combined with SWE shows promise for predicting pCR in invasive breast cancer undergoing NAC.</p>

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The utilization of CEUS and SWE for predicting pathological complete response to neoadjuvant chemotherapy for invasive breast cancer

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年2月5日

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  • Yingyan Wang,
  • Xuanli Jiang,
  • Yongyi Jiao,
  • Bingjie Yang,
  • Pingping Wang,
  • Huiming Shen,
  • Jiajia Xu,
  • Min Qi,
  • Hongyuan Shen,
  • Jiahao Han,
  • Danlu Li,
  • Danlei Song,
  • Jia Li

摘要

To evaluate the potential value of combining contrast-enhanced ultrasound (CEUS) with shear wave elastography (SWE) for predicting pathological complete response (pCR) in patients with breast cancer receiving neoadjuvant chemotherapy (NAC). Ultrasound (US), CEUS and SWE examinations were performed before and after NAC. The maximum tumor diameter on US (DUS) and CEUS (DCEUS), the maximum stiffness of SWE (Emax), their changes and consistency with the postoperative pathological analysis were evaluated, and their predictive value was compared using the receiver operating characteristic (ROC) curve. 60 patients were included among whom 28 (46.7%) achieved pCR and 32 (53.3%) exhibited non-pCR. The changes in DCEUS and Emax were significantly correlated with pCR (p < 0.005). ΔDCEUS% differed significantly between pCR and non-pCR groups across all molecular subtypes. However, ΔEmax% differed significantly in ER negative, PR negative and Her-2 negative breast cancer after NAC. The combination of ΔDCEUS% and ΔEmax% demonstrated superior predictive ability for NAC response, with an area under the curve (AUC) of 0.906, outperforming ΔDCEUS% (AUC 0.871) or ΔEmax% (AUC 0.722) alone. CEUS combined with SWE shows promise for predicting pCR in invasive breast cancer undergoing NAC.