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<p>Ultraviolet (UV) radiation is a primary environmental stimulus for skin hyperpigmentation. <i>Polianthes tuberosa L</i>. (PT), rich in polyphenols and flavonoids, possesses antioxidant and anti-inflammatory properties, yet the anti-melanogenic mechanism of the PT extract (PTE) remains unexplored. Network pharmacology revealed nuclear factor erythroid-derived 2-like 2, superoxide dismutase 1, nuclear factor kappa B subunit 1, and interleukin-6 as core targets, suggesting that PTE may coordinately modulate oxidative stress and inflammation. Consistent with this prediction, PTE dose-dependently suppressed UV-induced intracellular reactive oxygen species generation in immortalized human keratinocyte cell line (HaCaT). Furthermore, PTE not only inhibited the UV-induced release of inflammatory cytokines and paracrine melanogenic factors in HaCaT cells, but also mitigated UV-induced collagen reduction in fibroblasts. In the mouse melanoma cell line B16F10, the PTE significantly suppressed melanogenesis and tyrosinase activity (<i>p</i> &lt; 0.001). Integration of transcriptomic and proteomic data provided a complementary view of molecular regulation at both the messenger RNA and protein levels. This convergent evidence indicated that PTE acts as a concurrent inhibitor of the cyclic adenosine monophosphate (cAMP)/protein kinase A/cAMP-response element binding protein and mitogen-activated protein kinase signaling axes, as validated by quantitative polymerase chain reaction and western blot analyses. This dual inhibition led to the downregulation of microphthalmia-associated transcription factor and its downstream melanogenic enzymes. Our findings underscore the potential of PTE as a multifaceted, natural whitening agent for cosmetic applications.</p>

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Polianthes tuberosa L. Extract suppresses melanogenesis through concurrent Inhibition of cAMP/CREB and MAPK signaling pathways

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年1月24日

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  • Qiaozhen Li,
  • Hui Zhu,
  • Teng Jiang,
  • Rubiao Hou,
  • Jinhua Li,
  • Xiaodong Yan,
  • Jing Wang

摘要

Ultraviolet (UV) radiation is a primary environmental stimulus for skin hyperpigmentation. Polianthes tuberosa L. (PT), rich in polyphenols and flavonoids, possesses antioxidant and anti-inflammatory properties, yet the anti-melanogenic mechanism of the PT extract (PTE) remains unexplored. Network pharmacology revealed nuclear factor erythroid-derived 2-like 2, superoxide dismutase 1, nuclear factor kappa B subunit 1, and interleukin-6 as core targets, suggesting that PTE may coordinately modulate oxidative stress and inflammation. Consistent with this prediction, PTE dose-dependently suppressed UV-induced intracellular reactive oxygen species generation in immortalized human keratinocyte cell line (HaCaT). Furthermore, PTE not only inhibited the UV-induced release of inflammatory cytokines and paracrine melanogenic factors in HaCaT cells, but also mitigated UV-induced collagen reduction in fibroblasts. In the mouse melanoma cell line B16F10, the PTE significantly suppressed melanogenesis and tyrosinase activity (p < 0.001). Integration of transcriptomic and proteomic data provided a complementary view of molecular regulation at both the messenger RNA and protein levels. This convergent evidence indicated that PTE acts as a concurrent inhibitor of the cyclic adenosine monophosphate (cAMP)/protein kinase A/cAMP-response element binding protein and mitogen-activated protein kinase signaling axes, as validated by quantitative polymerase chain reaction and western blot analyses. This dual inhibition led to the downregulation of microphthalmia-associated transcription factor and its downstream melanogenic enzymes. Our findings underscore the potential of PTE as a multifaceted, natural whitening agent for cosmetic applications.