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<p>This study assessed the feasibility of posterior mitral valve leaflet and subvalvular reconstruction in an acute porcine model using a novel 2-ply vacuum-pressed small intestinal submucosal extracellular matrix (SIS-ECM) patch. Reconstruction was performed in an acute 80-kg porcine model (n = 7), using a novel 2-ply vacuum-pressed SIS-ECM (CorMatrix) patch for posterior mitral reconstruction. Echocardiography and left ventricular pressure were assessed pre- and post-interventional. Sonomicrometry was used to evaluate the geometry and valve dynamics. The reconstructed mitral valves were all fully competent. The peak left atrial pressure at baseline and post-reconstruction was 9.9 (1.1) vs 9.9 (1.0) mmHg, p = 0.676, diff = 0.002 mmHg, 95% CI: [-1.06;1.05], and the mean trans-mitral pressure difference was 4.5 (2.3) vs 4.1 (2.3) mmHg, p = 0.063, diff = -0.40, 95% CI: [-2,73;1.93] The out-of-plane characteristics and subvalvular geometry of the mitral valve were preserved after reconstruction. Slight atrial bending of the reconstructed posterior leaflet and systolic annular ballooning were observed. In an acute porcine model, we successfully reconstructed the posterior mitral valve and subvalvular apparatus using our modified 2-ply vacuum-pressed SIS-ECM patch. The bioscaffold demonstrated short-term durability in vivo, warranting further investigation of its long-term durability.</p>

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Functional competency of a novel 2-ply vacuum-pressed biological scaffold for entire posterior mitral valve reconstruction

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年1月14日

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  • Johannes H. Jedrzejczyk,
  • Frederik T. Andersen,
  • Alexander E. Kaspersen,
  • Jens T. Væsel,
  • Dennis O. Ammitzskov,
  • Søren N. Skov,
  • J. Michael Hasenkam,
  • Marcell J. Tjørnild

摘要

This study assessed the feasibility of posterior mitral valve leaflet and subvalvular reconstruction in an acute porcine model using a novel 2-ply vacuum-pressed small intestinal submucosal extracellular matrix (SIS-ECM) patch. Reconstruction was performed in an acute 80-kg porcine model (n = 7), using a novel 2-ply vacuum-pressed SIS-ECM (CorMatrix) patch for posterior mitral reconstruction. Echocardiography and left ventricular pressure were assessed pre- and post-interventional. Sonomicrometry was used to evaluate the geometry and valve dynamics. The reconstructed mitral valves were all fully competent. The peak left atrial pressure at baseline and post-reconstruction was 9.9 (1.1) vs 9.9 (1.0) mmHg, p = 0.676, diff = 0.002 mmHg, 95% CI: [-1.06;1.05], and the mean trans-mitral pressure difference was 4.5 (2.3) vs 4.1 (2.3) mmHg, p = 0.063, diff = -0.40, 95% CI: [-2,73;1.93] The out-of-plane characteristics and subvalvular geometry of the mitral valve were preserved after reconstruction. Slight atrial bending of the reconstructed posterior leaflet and systolic annular ballooning were observed. In an acute porcine model, we successfully reconstructed the posterior mitral valve and subvalvular apparatus using our modified 2-ply vacuum-pressed SIS-ECM patch. The bioscaffold demonstrated short-term durability in vivo, warranting further investigation of its long-term durability.