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<p>This study aimed to investigate the biological activity of essential oils (EOs) of <i>Artemisia abrotanum</i>, <i>Lavandula dentata</i>, <i>Cymbopogon citratus</i> and <i>Laurus nobilis</i> as anti-inflammatory and cancer chemopreventive activities. The anti-inflammatory activity was evaluated using lipopolysaccharides-induced nitric oxide (NO) inhibition on murine macrophage cells (RAW264.7) and cancer chemo-preventive influence was assessed in vitro utilizing Hepa1c1c7 murine carcinoma cells. The EO of <i>A. abrotanum</i> has the most potential activity toward inhibition of NO release, recording 96.6 ± 0.1%, as estimated by Greiss assay. Followed by EOs of <i>L. dentata</i> and <i>L. nobilis</i> with 63.6 ± 0.11 and 37.0 ± 0.23%, respectively. At the protein expression level, western blotting technique was used to evaluate the expression of iNOS. The EO of <i>A. abrotanum</i> at 100&#xa0;µg/ml exhibited a very high impact on inhibiting iNOS expression, followed by EOs of <i>L. dentata</i> and <i>L. nobilis</i>. On the other hand, pre-screening concentration (100&#xa0;µg/ml) revealed that the EOs of <i>L. dentata</i> and <i>A. abrotanum</i> have moderate potency to induce expression of chemo-preventive marker NQO1. The results revealed that the EO of <i>A. abrotanum</i> had strong anti-inflammatory activity. While the EOs of <i>L. dentata</i> and <i>A. abrotanum</i> have moderate potency to induce cancer chemoprevention.</p>

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Anti-inflammatory and cancer chemopreventive potential of essential oils from some cultivated plants in Egypt

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年1月29日

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  • Mohammed I. Ali,
  • Ahmed R. Hamed,
  • Emad M. Hassan,
  • Faten M. Abou elella,
  • Sayed A. El-Toumy,
  • Ahmed M. Aboul-Enein

摘要

This study aimed to investigate the biological activity of essential oils (EOs) of Artemisia abrotanum, Lavandula dentata, Cymbopogon citratus and Laurus nobilis as anti-inflammatory and cancer chemopreventive activities. The anti-inflammatory activity was evaluated using lipopolysaccharides-induced nitric oxide (NO) inhibition on murine macrophage cells (RAW264.7) and cancer chemo-preventive influence was assessed in vitro utilizing Hepa1c1c7 murine carcinoma cells. The EO of A. abrotanum has the most potential activity toward inhibition of NO release, recording 96.6 ± 0.1%, as estimated by Greiss assay. Followed by EOs of L. dentata and L. nobilis with 63.6 ± 0.11 and 37.0 ± 0.23%, respectively. At the protein expression level, western blotting technique was used to evaluate the expression of iNOS. The EO of A. abrotanum at 100 µg/ml exhibited a very high impact on inhibiting iNOS expression, followed by EOs of L. dentata and L. nobilis. On the other hand, pre-screening concentration (100 µg/ml) revealed that the EOs of L. dentata and A. abrotanum have moderate potency to induce expression of chemo-preventive marker NQO1. The results revealed that the EO of A. abrotanum had strong anti-inflammatory activity. While the EOs of L. dentata and A. abrotanum have moderate potency to induce cancer chemoprevention.