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<p>Foot-and-mouth disease (FMD) is a highly contagious viral disease of domesticated animals that causes major economic losses globally. In this meta-analysis, 29 studies were evaluated using a random-effects model to analyze the efficacy of FMD vaccines. The quantifying heterogeneity between the groups was low (tau<sup>2</sup> = 0.000, tau = 0.000, and I<sup>2</sup> = 0.0% [0.0%; 24.6%]). The meta-analysis revealed that the inactivated vaccine provides the best protection among different vaccine types, with the following ranking from highest to lowest efficacy: inactivated vaccine &gt; mRNA vaccine &gt; <i>E. coli</i> vaccine &gt; plant vaccine &gt; recombinant virus vaccine &gt; phage vaccine &gt; synthesize vaccine &gt; DNA vaccine &gt; negative control. The findings revealed that the inactivated vaccine provides the best protection among the different types of vaccines. Based on these findings, we recommend using inactivated vaccines as controls in the development of novel vaccines, as they achieved the highest efficacy among all evaluated vaccine types.</p>

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A meta-analysis on the effectiveness of serotype O foot-and-mouth disease vaccines

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年5月2日

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  • Jiao Jiao,
  • Haihua Yang,
  • Zhenqi Liang,
  • Yanhui Pan,
  • Jiaxin Yang,
  • Wenli Zhang,
  • Peng Wu

摘要

Foot-and-mouth disease (FMD) is a highly contagious viral disease of domesticated animals that causes major economic losses globally. In this meta-analysis, 29 studies were evaluated using a random-effects model to analyze the efficacy of FMD vaccines. The quantifying heterogeneity between the groups was low (tau2 = 0.000, tau = 0.000, and I2 = 0.0% [0.0%; 24.6%]). The meta-analysis revealed that the inactivated vaccine provides the best protection among different vaccine types, with the following ranking from highest to lowest efficacy: inactivated vaccine > mRNA vaccine > E. coli vaccine > plant vaccine > recombinant virus vaccine > phage vaccine > synthesize vaccine > DNA vaccine > negative control. The findings revealed that the inactivated vaccine provides the best protection among the different types of vaccines. Based on these findings, we recommend using inactivated vaccines as controls in the development of novel vaccines, as they achieved the highest efficacy among all evaluated vaccine types.