Scholarlink

<p>To assess macular and optic disc choriocapillary flow deficit (CCFD) and vessel density (VD) in myopic children by OCT-angiography. 280 eyes of 280 subjects were included and divided into the non-myopia (<i>n</i> = 96), low myopia (<i>n</i> = 95), and moderate myopia (<i>n</i> = 89) groups. We analyzed the following factors: CCFD density and size, choroidal vascularity index, choriocapillary VD, retinal VD. The moderate myopia group showed significantly higher CCFD density and size (<i>p</i> &lt; 0.05). There were significant linear correlations between CCFD density and axial length (AL), spherical equivalent (SE), average corneal curvature (AVK), and CCFD size and SE (all <i>p</i> &lt; 0.05). Breakpoints were identified at SE values of −1.25 and −1.14D in relation to CCFD density and CCFD size (all <i>p</i> &lt; 0.05). The moderate myopia group exhibited significantly increased and decreased radial peripapillary capillaries VD and retinal nerve fiber layer thickness in the temporal and nasal optic disc regions respectively (all <i>p</i> &lt; 0.05). CCFD demonstrated a significant increase and correlation with AL and SE, suggesting that CCFD may serve as a more sensitive indicator of alternations in choroidal blood flow. It offers a novel perspective for investigating myopia progression associated with alterations in choroidal blood flow.</p><p><b>Trial registration number</b> ChiCTR2400087513.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Assessment of choriocapillary flow deficits in myopic children by optical coherence tomography angiography

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年5月3日

查看全文
  • Fangyuan Zhou,
  • Yilin Yuan,
  • Yishuang Xu,
  • Zhuo Huang,
  • Fuxin Wang,
  • Zhen Chen,
  • Changzheng Chen,
  • Dihao Hua

摘要

To assess macular and optic disc choriocapillary flow deficit (CCFD) and vessel density (VD) in myopic children by OCT-angiography. 280 eyes of 280 subjects were included and divided into the non-myopia (n = 96), low myopia (n = 95), and moderate myopia (n = 89) groups. We analyzed the following factors: CCFD density and size, choroidal vascularity index, choriocapillary VD, retinal VD. The moderate myopia group showed significantly higher CCFD density and size (p < 0.05). There were significant linear correlations between CCFD density and axial length (AL), spherical equivalent (SE), average corneal curvature (AVK), and CCFD size and SE (all p < 0.05). Breakpoints were identified at SE values of −1.25 and −1.14D in relation to CCFD density and CCFD size (all p < 0.05). The moderate myopia group exhibited significantly increased and decreased radial peripapillary capillaries VD and retinal nerve fiber layer thickness in the temporal and nasal optic disc regions respectively (all p < 0.05). CCFD demonstrated a significant increase and correlation with AL and SE, suggesting that CCFD may serve as a more sensitive indicator of alternations in choroidal blood flow. It offers a novel perspective for investigating myopia progression associated with alterations in choroidal blood flow.

Trial registration number ChiCTR2400087513.