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<p>European guidelines require packed red blood cells (pRBC) to be stored at 2–6&#xa0;°C. However, negative temperature shifts can occur especially in prehospital transfusion. We investigated the impact of sub-zero temperature exposure on pRBC storage quality. At day 6 post donation (D6), three cohorts (14 pRBC) were put on a supercooled table for 10&#xa0;h at either − 1&#xa0;°C, -5&#xa0;°C, and − 11&#xa0;°C and compared to a control cohort. Hemolysis, pH and plasma biochemistry were evaluated weekly until D49. Storage-induced micro-erythrocytes (SMEs) were quantified as a surrogate marker for transfusion recovery. The primary endpoint was compliance with European storage standards at D42. The three sub-zero-exposed cohorts met standards at D42. Differences in hemolysis, pH, plasma biochemistry, or SMEs between exposed and control cohorts were non-statistically and/or non-clinically significant. Ten hours exposure to sub-zero temperatures down to -11&#xa0;°C by conduction maintains storage quality of pRBCs, enabling a wiser risk assessment for potential transfusion use.</p>

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Exposure to sub-zero temperatures down to -11 °C does not impact packed red cells storage quality

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年4月19日

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  • Clément Derkenne,
  • Manon Vavasseur,
  • Olivier Javaudin,
  • Yann Daniel,
  • Simon-Pierre Corcostegui,
  • Paul Lely,
  • Elodie Ormes,
  • Hélène Desudde,
  • Sandrine Pons,
  • Angela Giannuzzo,
  • Matthieu Heidet,
  • Philippe Vest,
  • Daniel Jost,
  • Michael Dussiot,
  • Albane Miron de l’Espinay,
  • Christophe Martinaud,
  • Pascal Amireault

摘要

European guidelines require packed red blood cells (pRBC) to be stored at 2–6 °C. However, negative temperature shifts can occur especially in prehospital transfusion. We investigated the impact of sub-zero temperature exposure on pRBC storage quality. At day 6 post donation (D6), three cohorts (14 pRBC) were put on a supercooled table for 10 h at either − 1 °C, -5 °C, and − 11 °C and compared to a control cohort. Hemolysis, pH and plasma biochemistry were evaluated weekly until D49. Storage-induced micro-erythrocytes (SMEs) were quantified as a surrogate marker for transfusion recovery. The primary endpoint was compliance with European storage standards at D42. The three sub-zero-exposed cohorts met standards at D42. Differences in hemolysis, pH, plasma biochemistry, or SMEs between exposed and control cohorts were non-statistically and/or non-clinically significant. Ten hours exposure to sub-zero temperatures down to -11 °C by conduction maintains storage quality of pRBCs, enabling a wiser risk assessment for potential transfusion use.