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<p>Based on the eutectic point phase diagram, a novel natural deep eutectic solvent (SER/GLU-DES) was prepared by a mixture of one mole of serine (SER) and one mole of glutaric acid (GLU), and characterized by various techniques. Then, it was used as a novel and potent catalyst for the synthesis of two sets of biologically important pyrazolopyranopyrimidines via a one-pot four-component condensation reaction of ethyl acetoacetate, hydrazinehydrate<b>/</b> phenylhydrazine, barbituric acid and aldehydes at 70&#xa0;°C, in solvent-free conditions.</p>

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Preparation and use of SER/GLU-based DES as a novel and potent catalyst for the green synthesis of pyrazolopyranopyrimidines

  • 期刊论文

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  • 发表日期：

    2025年4月19日

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  • Nastaran Dehnokhalaji,
  • Davood Habibi,
  • Arezo Monem,
  • Afagh Ranjbaran

摘要

Based on the eutectic point phase diagram, a novel natural deep eutectic solvent (SER/GLU-DES) was prepared by a mixture of one mole of serine (SER) and one mole of glutaric acid (GLU), and characterized by various techniques. Then, it was used as a novel and potent catalyst for the synthesis of two sets of biologically important pyrazolopyranopyrimidines via a one-pot four-component condensation reaction of ethyl acetoacetate, hydrazinehydrate/ phenylhydrazine, barbituric acid and aldehydes at 70 °C, in solvent-free conditions.