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<p>Research suggests a potential link between varicella zoster virus (VZV) and Parkinson’s disease (PD), but the causal relationship between anti-VZV IgG levels and PD is not well understood. Using two-sample Mendelian Randomization (MR), we assessed the causal impact of anti-VZV IgG levels on PD risk and progression. Our study found a significant association between higher anti-VZV IgG levels and an increased risk of PD. For PD progression, higher anti-VZV IgG levels were linked to a greater risk of constipation, insomnia, and Restless Legs. These findings remained consistent after sensitivity analyses. In conclusion, our study suggests that elevated anti-VZV IgG levels may contribute to an increased risk and progression of PD, supporting a potential causal link that warrants further mechanistic investigation.</p>

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Impact of anti-VZV IgG levels on Parkinson’s disease risk and progression: a Mendelian randomization analysis

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年4月8日

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  • Jinxing Sun,
  • Xiangchen Li,
  • Shengmei Ma,
  • Haopeng Lin,
  • Zhenke Li,
  • Junheng Jia,
  • Yasaman Alizadeh,
  • Qianqian Wu,
  • Ying Hou,
  • Hong Wang,
  • Qi Wang,
  • Guangjian Zhang,
  • Xingang Li,
  • Weiguo Li,
  • Chao Zhang

摘要

Research suggests a potential link between varicella zoster virus (VZV) and Parkinson’s disease (PD), but the causal relationship between anti-VZV IgG levels and PD is not well understood. Using two-sample Mendelian Randomization (MR), we assessed the causal impact of anti-VZV IgG levels on PD risk and progression. Our study found a significant association between higher anti-VZV IgG levels and an increased risk of PD. For PD progression, higher anti-VZV IgG levels were linked to a greater risk of constipation, insomnia, and Restless Legs. These findings remained consistent after sensitivity analyses. In conclusion, our study suggests that elevated anti-VZV IgG levels may contribute to an increased risk and progression of PD, supporting a potential causal link that warrants further mechanistic investigation.