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<p>The size of hepatic microwave ablations (MWA) is often difficult to predict due to cooling effects from liver vessels. This study introduces a simplified predictive model, the Ablation Success Ratio (ASR), which estimates the likelihood of a successful ablation based on tumor size and specific ablation parameters. The ASR model is based on the three-dimensional minimum ablation radius (r<sub>3Dmin</sub>), defining the spherical region within which complete ablation is achieved. To validate the ASR, standardized MWAs were performed in an ex vivo porcine liver model using a glass tube to simulate the vascular cooling effect. Ablations (<i>n</i> = 148) were conducted at 100&#xa0;W for 5&#xa0;min, with antenna-to-vessel (A-V) distances set at 2.5, 5.0, and 10.0&#xa0;mm. Subsequently, the r<sub>3Dmin</sub> was calculated. Without vascular cooling (0&#xa0;ml/min, corresponding to an intraoperative Pringle maneuver), an ASR of 100% was achieved for ablation diameters up to 20&#xa0;mm. However, in the presence of vascular cooling (1–500&#xa0;ml/min), the ASR reached 100% only for ablation diameters up to 12&#xa0;mm, demonstrating that the ASR effectively includes the impact of vascular cooling effects. The ASR is a promising and simple approach for predicting ablation success while also accounting for vascular cooling effects in hepatic MWA.</p>

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Optimizing microwave ablation planning with the ablation success ratio

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年3月26日

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  • Christina A. Neizert,
  • Hoang N. C. Do,
  • Miriam Zibell,
  • David Sinden,
  • Christian Rieder,
  • Jakob Albrecht,
  • Stefan M. Niehues,
  • Kai S. Lehmann,
  • Franz G. M. Poch

摘要

The size of hepatic microwave ablations (MWA) is often difficult to predict due to cooling effects from liver vessels. This study introduces a simplified predictive model, the Ablation Success Ratio (ASR), which estimates the likelihood of a successful ablation based on tumor size and specific ablation parameters. The ASR model is based on the three-dimensional minimum ablation radius (r3Dmin), defining the spherical region within which complete ablation is achieved. To validate the ASR, standardized MWAs were performed in an ex vivo porcine liver model using a glass tube to simulate the vascular cooling effect. Ablations (n = 148) were conducted at 100 W for 5 min, with antenna-to-vessel (A-V) distances set at 2.5, 5.0, and 10.0 mm. Subsequently, the r3Dmin was calculated. Without vascular cooling (0 ml/min, corresponding to an intraoperative Pringle maneuver), an ASR of 100% was achieved for ablation diameters up to 20 mm. However, in the presence of vascular cooling (1–500 ml/min), the ASR reached 100% only for ablation diameters up to 12 mm, demonstrating that the ASR effectively includes the impact of vascular cooling effects. The ASR is a promising and simple approach for predicting ablation success while also accounting for vascular cooling effects in hepatic MWA.