Scholarlink

<p>The impact on immunogenicity and efficacy of SARS-CoV-2 vaccination in people with prior COVID-19 could differ depending on timing of vaccination and number of doses. The VATICO study randomized 66 hospitalized recovered COVID-19 individuals to receive either immediate or deferred vaccination, with one or two doses of mRNA SARS-CoV-2 vaccines. We measured binding and neutralizing antibodies against SARS-CoV-2 at enrollment and longitudinally. Median (IQR) time from SARS-CoV-2 infection to first vaccination was 68 (53–75) days in the immediate group, and 151 (137–173) days in the deferred group. At week 48, timing or number of vaccine doses did not influence the change in antibody levels relative to baseline. Adherence to the assigned vaccine regimen was lower in the deferred group, particularly in participants receiving two doses. Although the study ultimately lacked adequate power to draw firm conclusions, these results suggest possible benefits of prompt vaccination after recovery from COVID-19.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

SARS-Cov-2 vaccination strategies in hospitalized recovered COVID-19 patients: a randomized clinical trial (VATICO Trial)

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年3月22日

查看全文
  • Sofía Sábato,
  • Susana Benet,
  • Angela J. Rogers,
  • Thomas A. Murray,
  • Melissa Skeans,
  • Beatriz Mothe,
  • Roger Paredes,
  • Ahmad Mourad,
  • Francis Kiweewa,
  • Dena Kamel,
  • Mamta K. Jain,
  • Joseph Lutaakome,
  • Mary Grace Nalubega,
  • Nicholus Sebudde,
  • Eleftherios Mylonakis,
  • Dominique L. Braun,
  • Timothy Hatlen,
  • Ivan Kimuli,
  • Cissy Kitko,
  • Henry Mugerwa,
  • Jonathan Kitonsa,
  • Kami Kim,
  • Phyllis C. Tien,
  • Jeroen Highbarger,
  • Ashley L. McCormack,
  • Adriana Sanchez,
  • Daniel D. Murray,
  • Abdel G. Babiker,
  • Victoria J. Davey,
  • D. Clark Files,
  • Annetine C. Gelijns,
  • Elizabeth S. Higgs,
  • Virginia L. Kan,
  • Gail V. Matthews,
  • Sarah L. Pett,
  • H. Clifford Lane,
  • Cavan Reilly,
  • Anna L. Goodman,
  • Jens D. Lundgren,
  • José Moltó,
  • H. Clifford Lane,
  • Elizabeth S. Higgs,
  • Susan E. Vogel,
  • John Tierney,
  • Mary C. Smolskis,
  • Laura A. McNay,
  • Sharon Segal Raim,
  • Katy Shaw-Saliba,
  • Mark Miller,
  • David Vallee,
  • Lucy Chung,
  • Nayon Kang,
  • Robin L. Dewar,
  • Ven Natarajan,
  • Weizhong Chang,
  • Brad T. Sherman,
  • Adam W. Rupert,
  • Helene Highbarger,
  • Michael Baseler,
  • Ashley McCormack,
  • Jeroen Highbarger,
  • Perrine Lallemand,
  • M. Tauseef Rehman,
  • Tom Imamichi,
  • Sylvain Laverdure,
  • Sharada Paudel,
  • Kyndal Cook,
  • Kendra Haupt,
  • Lisheng Dai,
  • M. Ayub Khan,
  • Allison Hazen,
  • Yunden Badralmaa,
  • Stacey J. Adam,
  • James D. Neaton,
  • Adam A. C. Burns,
  • Amy Carlsen,
  • Anita Carter,
  • Eileen Denning,
  • Alain DuChene,
  • Kate Eckroth,
  • Nicole Engen,
  • Alex Frase,
  • Greg Grandits,
  • Merrie Harrison,
  • Payton Kaiser,
  • Sue Meger,
  • Shweta Sharma Mistry,
  • Thomas Murray,
  • Kien Quan,
  • Siu Fun Quan,
  • Cavan Reilly,
  • Melissa Skeans,
  • Greg Thompson,
  • Jamie Walski,
  • Deborah Wentworth,
  • Claire Rappoport,
  • Annetine Gelijns,
  • Ellen Moquete,
  • Karen O’Sullivan,
  • Evan Accardi,
  • Sarah Burris,
  • Alan Moskowitz,
  • Mary Beth Marks,
  • Jens D. Lundgren,
  • Dorthe Raben,
  • Daniel D. Murray,
  • Tomas O. Jensen,
  • Bitten Aagaard,
  • Charlotte B. Nielsen,
  • Katharina Krapp,
  • Katja Lisa Kanne,
  • Abdel G. Babiker,
  • Sarah L. Pett,
  • Fleur Hudson,
  • Mahesh K. B. Parmar,
  • Anna L. Goodman,
  • Jonathan Badrock,
  • Dipa Noor,
  • Adam Gregory,
  • Katharine Goodall,
  • Nicola Harris,
  • James Wyncoll,
  • Wesley H. Self,
  • Adit A. Ginde,
  • Matthew W. Semler,
  • Todd W. Rice,
  • Crystal North,
  • Samuel Brown,
  • Angela Rogers,
  • Cathryn Oldmixon,
  • Margaret Hays,
  • Mark Polizzotto,
  • Sally Hough,
  • Katherine Ognenovska,
  • Catherine Carey,
  • Christina C. Chang,
  • Nila J. Dharan,
  • Gail Matthews,
  • Anthony Kelleher,
  • Sophie Virachit,
  • Sarah Davidson,
  • Daniel J. Bice,
  • Ruth Flynn,
  • Gesalit Cabrera,
  • Victoria J. Davey,
  • Kousick Biswas,
  • Tammy Bremer,
  • Tara Burke,
  • Brittany Koker,
  • Anne Davis-Karim,
  • David Pittman,
  • Shikha S. Vasudeva,
  • Virginia Kan,
  • Amy Weintrob,
  • Adriana Sanchez,
  • Laura Poplieski,
  • Kimberley Viens,
  • Melissa Turner,
  • Peter Smith,
  • Thomas Holland,
  • Ahmad Mourad,
  • Mary Motta,
  • Mamta Jain,
  • Timothy Hatlen,
  • Betty Anderson,
  • Mario Guerrero,
  • Dannae Martin,
  • Ramiro Correa,
  • Avon Vargas,
  • Gabe Hartnell,
  • Cynthia Temblador,
  • Eleftherios Mylonakis,
  • Quynh-Lam Tran,
  • Ralph D. Rogers,
  • Fadi Shehadeh,
  • Evangelia K. Mylona,
  • Matthew Kaczynski,
  • Srikanth Ramachandruni,
  • Brenda Hernandez,
  • Melissa Shadle,
  • Polly Mock,
  • Phyllis Tien,
  • Heather Freasier,
  • Angela J. Rogers,
  • Rosemary Vojnik,
  • Jennifer G. Wilson,
  • Kami Kim,
  • D. Clark Files,
  • Kevin W. Gibbs,
  • Lori Flores,
  • D. Rafael Palacios,
  • Peter Chen,
  • Susan Jackson,
  • Antonina Caudill,
  • Brittany Mattison,
  • Lea Dahlke,
  • Ken Kunisaki,
  • Edward Gardner,
  • Shikha Vasudeva,
  • Stephanie Nagy-Agren,
  • Tracy Ochalek,
  • Ayesha Khan,
  • Carolyn Gould,
  • Amy Weintrob,
  • Virginia Kan,
  • Adriana Sánchez,
  • Laura Popielski,
  • Kimberley Viens,
  • Melissa Turner,
  • Joseph Lutaakome,
  • Cissy Kityo,
  • Henry Mugerwa,
  • Francis Kiweewa,
  • Ivan Kimuli,
  • Gloria Lubega,
  • Moses Kibirige,
  • Margaret Nalaaki,
  • Deus Wangi,
  • Phiona Nabagala,
  • Francis Kiweewa,
  • Nicholus Sebudde,
  • Mary Grace Nalubega,
  • Doreen Ebong,
  • Harrient Tino,
  • Robert Kidega,
  • Henry Mugerwa,
  • Daizy Faith Oryem,
  • Emmanuel Ocung,
  • Geoffery Amone,
  • Florence Apio,
  • Deborah Nyiraguhirwa,
  • Priscilla Irene Alum,
  • Carol Nantongo,
  • Francis Kiweewa,
  • Ivan Kimuli,
  • Bruce Kirenga,
  • Queen Mbabazi,
  • Ivan Segawa,
  • Angella Atukunda,
  • Jonathan Kitonsa,
  • Naboth Tukamwesiga,
  • Hadijah Naluyinda,
  • Julian Nandhego,
  • Phiona Nabaggala,
  • Moses Kibirige,
  • Gloria Lubega,
  • Margaret Nalaaki,
  • Deus Wangi,
  • Roger Kisuule,
  • Joseph Lutaakome,
  • Evelyn Nabankema,
  • Ivan Okoth,
  • Oscar Mugerwa,
  • Nabuuma Theresa,
  • Roger Paredes,
  • Maria Expósito,
  • José Badillo,
  • Ana Martínez,
  • Elena Abad,
  • Beatriz Mothe,
  • José Moltó,
  • Susana Benet,
  • Sofia Sabato,
  • Antoni Trilla,
  • Leire Balerdi,
  • Almudena Legarda,
  • Montserrat Roldan,
  • José Muñoz,
  • Eduardo Fernández-Cruz,
  • Marisa Di Natale,
  • Sergiu Padure,
  • Jimena Gomez,
  • Christina Ausín,
  • Magda Campins,
  • Eva del Amo,
  • Xavier Martínez,
  • Susana Otero,
  • Blanca Borras,
  • Jose Luis Morales-Rull,
  • Anna Maria Moreno Pena,
  • Laia Martínez,
  • Raquel Martí,
  • Huldrych F. Günthard,
  • Dominique L. Braun,
  • Emily West,
  • Manuela Grüttner-Durmaz,
  • Carmen Tallón de Lara,
  • Antonio Amodeo,
  • Nnakelu Eriobu,
  • Vivian Kwaghe,
  • Zaiyad Habib,
  • Godwin Idoko,
  • Blessing Uche,
  • Barnaby E. Young,
  • Po Ying Chia,
  • Sean W. X. Ong,
  • Shaiu Hui Diong,
  • He Ping Yeo

摘要

The impact on immunogenicity and efficacy of SARS-CoV-2 vaccination in people with prior COVID-19 could differ depending on timing of vaccination and number of doses. The VATICO study randomized 66 hospitalized recovered COVID-19 individuals to receive either immediate or deferred vaccination, with one or two doses of mRNA SARS-CoV-2 vaccines. We measured binding and neutralizing antibodies against SARS-CoV-2 at enrollment and longitudinally. Median (IQR) time from SARS-CoV-2 infection to first vaccination was 68 (53–75) days in the immediate group, and 151 (137–173) days in the deferred group. At week 48, timing or number of vaccine doses did not influence the change in antibody levels relative to baseline. Adherence to the assigned vaccine regimen was lower in the deferred group, particularly in participants receiving two doses. Although the study ultimately lacked adequate power to draw firm conclusions, these results suggest possible benefits of prompt vaccination after recovery from COVID-19.