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<p><i>Klebsiella pneumoniae</i> (KPn) colonizes multiple anatomical sites and is a leading cause of invasive disease and death in African children; however, there is no comparative genomic analysis between colonizing and invasive strains. This study investigated the genomic relatedness of KPn colonizing and invasive isolates in South African infants; and evaluated the relative invasiveness of KPn isolates based on sequence types (ST), capsular (KL), and lipopolysaccharide (O) loci by calculating case-carrier ratios (CCRs). There was less genomic diversity amongst invasive (22 ST,&#xa0;17&#xa0;K-loci) than colonizing isolates (31 ST,&#xa0;29&#xa0;K-loci), with invasive isolates being 8.59-fold and 3.49-fold more likely to harbour genes encoding for multi-drug resistance and yersiniabactin production compared with colonizing isolates. The CCRs for KL102 and O1/O2v2 were &gt; 1, and &lt; 1 for KL8, ST1414, and O1O2v1. Identifying high-risk strains, including KL102 and O1O2v2, that may have a higher potential to cause invasive disease, could enhance risk assessment and management strategies in vulnerable populations.</p>

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Genomic relatedness of colonizing and invasive disease Klebsiella pneumoniae isolates in South African infants

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年3月7日

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  • Courtney P. Olwagen,
  • Alane Izu,
  • Shama Khan,
  • Lara Van der Merwe,
  • Nicholas J. Dean,
  • Fikile C. Mabena,
  • Stephanie Jones,
  • Gaurav Kwatra,
  • Lubomira Andrew,
  • Urvi Rajyaguru,
  • Robert G. K. Donald,
  • Raphael Simon,
  • Mohamed Said,
  • Firdose L. Nakwa,
  • Jeannette Wadula,
  • Renate Strehlau,
  • Anika M. van Niekerk,
  • Niree Naidoo,
  • Yogandree Ramsamy,
  • Sithembiso C. Velaphi,
  • Ziyaad Dangor,
  • Shabir A. Madhi

摘要

Klebsiella pneumoniae (KPn) colonizes multiple anatomical sites and is a leading cause of invasive disease and death in African children; however, there is no comparative genomic analysis between colonizing and invasive strains. This study investigated the genomic relatedness of KPn colonizing and invasive isolates in South African infants; and evaluated the relative invasiveness of KPn isolates based on sequence types (ST), capsular (KL), and lipopolysaccharide (O) loci by calculating case-carrier ratios (CCRs). There was less genomic diversity amongst invasive (22 ST, 17 K-loci) than colonizing isolates (31 ST, 29 K-loci), with invasive isolates being 8.59-fold and 3.49-fold more likely to harbour genes encoding for multi-drug resistance and yersiniabactin production compared with colonizing isolates. The CCRs for KL102 and O1/O2v2 were > 1, and < 1 for KL8, ST1414, and O1O2v1. Identifying high-risk strains, including KL102 and O1O2v2, that may have a higher potential to cause invasive disease, could enhance risk assessment and management strategies in vulnerable populations.