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<p>The level of protection against SARS-CoV-2 breakthrough infections conferred by the presence of anti-S1 SARS-CoV-2 antibodies (IgGs) in cancer patients is still understudied. This work examines the existence of an anti-S1 immunoglobulin G (IgG) -based correlate of protection (CoP) established by prospectively collected observational data about breakthrough infections with different SARS-CoV-2 variants in a large cohort study with vaccinated cancer patients. 760 cancer patients were longitudinally followed-up, starting before first vaccination until six months after second booster. Anti-S1 SARS-CoV-2 IgGs were quantified in serum samples (<i>N</i> = 2958) and breakthrough infections were monitored using questionnaires, routine COVID-19 testing and medical chart review. A Generalized Estimating Equations approach was used to model the binary infection status as endpoint in relation to anti-S1 IgG titers. It is observed that higher anti-S1 IgG titers correspond to a lower probability of breakthrough infection. For the early pandemic phase, a protective anti-S1 IgG titer above 20.42 BAU/mL was observed. However, with the emergence of the Omicron variant, higher anti-S1 IgG titers are required to be protective, but no clear CoP could be identified.</p>

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Cracking the code of a correlate of protection against SARS-CoV-2 breakthrough infection in cancer patients

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年3月6日

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  • Yana Debie,
  • Irene Garcia-Fogeda,
  • Lander Willem,
  • Ella Roelant,
  • Lise Verbruggen,
  • Greetje Vanhoutte,
  • Lieselot Croes,
  • Christof Vulsteke,
  • Wim Demey,
  • Willem Lybaert,
  • Marianne Hanssens,
  • Alain Bols,
  • Johan Van ongeval,
  • Ann De Becker,
  • Hilde Jansens,
  • Maria E. Goossens,
  • Annelies Janssens,
  • Hans Prenen,
  • Sébastien Anguille,
  • Marc Peeters,
  • Peter A. van Dam,
  • Niel Hens,
  • Steven Abrams,
  • Timon Vandamme

摘要

The level of protection against SARS-CoV-2 breakthrough infections conferred by the presence of anti-S1 SARS-CoV-2 antibodies (IgGs) in cancer patients is still understudied. This work examines the existence of an anti-S1 immunoglobulin G (IgG) -based correlate of protection (CoP) established by prospectively collected observational data about breakthrough infections with different SARS-CoV-2 variants in a large cohort study with vaccinated cancer patients. 760 cancer patients were longitudinally followed-up, starting before first vaccination until six months after second booster. Anti-S1 SARS-CoV-2 IgGs were quantified in serum samples (N = 2958) and breakthrough infections were monitored using questionnaires, routine COVID-19 testing and medical chart review. A Generalized Estimating Equations approach was used to model the binary infection status as endpoint in relation to anti-S1 IgG titers. It is observed that higher anti-S1 IgG titers correspond to a lower probability of breakthrough infection. For the early pandemic phase, a protective anti-S1 IgG titer above 20.42 BAU/mL was observed. However, with the emergence of the Omicron variant, higher anti-S1 IgG titers are required to be protective, but no clear CoP could be identified.