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<p>Transcranial alternating current stimulation (tACS) is an efficient neuromodulation technique to enhance cognitive function in a non-invasive manner. Using functional magnetic resonance imaging, we investigated whether a cross-frequency coupled tACS protocol with a phase lag (45 and 180 degrees) between the central executive and the default mode networks modulated working-memory performance. We found tACS-phase-dependent modulation of task performance reflected in hippocampal activation and task-related functional connectivity. Our observations provide a neurophysiological basis for neuromodulation and a feasible non-invasive approach to selectively stimulate a task-relevant deep brain structure. Overall, our study highlights the potential of tACS as a powerful tool for enhancing cognitive function and sheds light on the underlying mechanisms of this technique.</p>

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Phase-lagged tACS between executive and default mode networks modulates working memory

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年3月17日

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  • Jeehye Seo,
  • Dongha Lee,
  • Dimitrios Pantazis,
  • Byoung-Kyong Min

摘要

Transcranial alternating current stimulation (tACS) is an efficient neuromodulation technique to enhance cognitive function in a non-invasive manner. Using functional magnetic resonance imaging, we investigated whether a cross-frequency coupled tACS protocol with a phase lag (45 and 180 degrees) between the central executive and the default mode networks modulated working-memory performance. We found tACS-phase-dependent modulation of task performance reflected in hippocampal activation and task-related functional connectivity. Our observations provide a neurophysiological basis for neuromodulation and a feasible non-invasive approach to selectively stimulate a task-relevant deep brain structure. Overall, our study highlights the potential of tACS as a powerful tool for enhancing cognitive function and sheds light on the underlying mechanisms of this technique.