Scholarlink

<p><i>Plasmodium falciparum</i> and <i>Toxoplasma gondii</i> are two apicomplexan parasites that can lead to severe complications for the newborn when contracted during pregnancy. This study explores the cross-reactivity of antibodies specific to both pathogens in pregnant women, exposed or not to malaria. The antibody response against full-length recombinant antigens from <i>P. falciparum</i> (<i>Pf</i>AMA1, <i>Pfs</i>48/45) and <i>T. gondii</i> (<i>Tg</i>AMA1, <i>Tg</i>SAG1, <i>Tg</i>GRA7), selected for their strong immunogenicity, was analysed on 150 plasma samples from women residing in Benin or France. The antibody functionality was assessed using <i>P. falciparum</i> in vitro Growth Inhibition Assay (GIA). As the main results, toxoplasmosis seropositive women with an ongoing <i>P. falciparum</i> infection better inhibited <i>P. falciparum</i> invasion compared to toxoplasmosis seronegative women (34.6% vs. 17.2%, <i>p</i> ≤ 0.01). Women with positive serologies for both parasites presented a significantly higher inhibition of <i>P. falciparum</i> invasion compared to those only seropositive for malaria (coef = 6.27, <i>p</i> = 0.076) in reference with double-negative women (coef = 11.35, <i>p</i> = 0.001). These data suggest that plasma samples containing anti-<i>T. gondii</i> IgG may contribute reducing the development of <i>P. falciparum</i> parasites. This study provides insight into the immune dynamics of the co-infection by these two apicomplexans with potential implications for developing cross-protective vaccines and therapies.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Functionality of Toxoplasma gondii antibodies in a population of Beninese pregnant women exposed to malaria

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年3月18日

查看全文
  • Mariama Souffou,
  • Célia Dechavanne,
  • Zaineb Kammoun,
  • Firmine Viwami,
  • Isabelle Gaugué,
  • Naima Beldjoudi,
  • Sébastien Dechavanne,
  • Nawal Sare,
  • André Garcia,
  • Magalie Dambrun,
  • Florence Migot-Nabias

摘要

Plasmodium falciparum and Toxoplasma gondii are two apicomplexan parasites that can lead to severe complications for the newborn when contracted during pregnancy. This study explores the cross-reactivity of antibodies specific to both pathogens in pregnant women, exposed or not to malaria. The antibody response against full-length recombinant antigens from P. falciparum (PfAMA1, Pfs48/45) and T. gondii (TgAMA1, TgSAG1, TgGRA7), selected for their strong immunogenicity, was analysed on 150 plasma samples from women residing in Benin or France. The antibody functionality was assessed using P. falciparum in vitro Growth Inhibition Assay (GIA). As the main results, toxoplasmosis seropositive women with an ongoing P. falciparum infection better inhibited P. falciparum invasion compared to toxoplasmosis seronegative women (34.6% vs. 17.2%, p ≤ 0.01). Women with positive serologies for both parasites presented a significantly higher inhibition of P. falciparum invasion compared to those only seropositive for malaria (coef = 6.27, p = 0.076) in reference with double-negative women (coef = 11.35, p = 0.001). These data suggest that plasma samples containing anti-T. gondii IgG may contribute reducing the development of P. falciparum parasites. This study provides insight into the immune dynamics of the co-infection by these two apicomplexans with potential implications for developing cross-protective vaccines and therapies.