Scholarlink

<p>Rigidity, a cardinal symptom of Parkinson’s disease (PD), remains challenging to assess objectively. A torque-angle instrument was developed to quantify muscle tone, providing two parameters: bias difference and elastic coefficient. This study aimed to investigate the association of the instrument-measured rigidity with clinical assessments and brain function. In 30 patients with PD, the muscle tone in both arms was evaluated. Ten with wearing-off phenomenon were assessed twice, off and on condition. Twentynine patients underwent brain perfusion single-photon emission computed tomography (SPECT), and expression of PD-related covariance pattern (PDRP) was computed. Bias difference and elastic coefficient showed positive correlations with physician-rated rigidity (<i>P</i> &lt; 0.002). Bias difference decreased after dopaminergic medication (<i>P</i> = 0.022) and was associated with lower body mass index (<i>P</i> = 0.012). Elastic coefficient positively correlated with the Unified PD Rating Scale Part III and PDRP scores (<i>P</i> &lt; 0.044). Furthermore, the higher bias difference correlated with decreased sensory-motor cortex and increased substantia nigra perfusion (<i>P</i> &lt; 0.001). The Torque-angle instrument is a viable tool for quantifying rigidity in PD. The bias difference reflects treatment responsiveness and is associated with the function in the sensory-motor cortex and substantia nigra. The elastic coefficient is indicative of overall Parkinsonism severity.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Clinical and brain functional correlates of instrumental rigidity measurement in Parkinson’s disease

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年3月7日

查看全文
  • Yoshikazu Nakano,
  • Shigeki Hirano,
  • Mitsuyoshi Tamura,
  • Yume Koizumi,
  • Yoshihisa Kitayama,
  • Michiko Izumi,
  • Masahide Suzuki,
  • Kosuke Yamagishi,
  • Yutaro Suzuki,
  • Shinobu Ikeda,
  • Ayaka Arase,
  • Tatsuya Yamamoto,
  • Yoshitaka Yamanaka,
  • Atsuhiko Sugiyama,
  • Kazumoto Shibuya,
  • Takuro Horikoshi,
  • Takashi Uno,
  • David Eidelberg,
  • Satoshi Kuwabara

摘要

Rigidity, a cardinal symptom of Parkinson’s disease (PD), remains challenging to assess objectively. A torque-angle instrument was developed to quantify muscle tone, providing two parameters: bias difference and elastic coefficient. This study aimed to investigate the association of the instrument-measured rigidity with clinical assessments and brain function. In 30 patients with PD, the muscle tone in both arms was evaluated. Ten with wearing-off phenomenon were assessed twice, off and on condition. Twentynine patients underwent brain perfusion single-photon emission computed tomography (SPECT), and expression of PD-related covariance pattern (PDRP) was computed. Bias difference and elastic coefficient showed positive correlations with physician-rated rigidity (P < 0.002). Bias difference decreased after dopaminergic medication (P = 0.022) and was associated with lower body mass index (P = 0.012). Elastic coefficient positively correlated with the Unified PD Rating Scale Part III and PDRP scores (P < 0.044). Furthermore, the higher bias difference correlated with decreased sensory-motor cortex and increased substantia nigra perfusion (P < 0.001). The Torque-angle instrument is a viable tool for quantifying rigidity in PD. The bias difference reflects treatment responsiveness and is associated with the function in the sensory-motor cortex and substantia nigra. The elastic coefficient is indicative of overall Parkinsonism severity.