Scholarlink

<p>This retrospective cohort study included all user of tumor necrosis factor-α inhibitors (TNFi), including etanercept, infliximab, adalimumab, and golimumab, among Korean patients with psoriasis and rheumatoid arthritis (N of user = 7,645) and the non-user who was diagnosed with same diseases, never used TNFi, and was served as the reference. Cumulative usage of TNFi was calculated between the newly diagnosed date and index date (2-year from the diagnosed date). Adjusted hazard ratio (aHR [95% confidence intervals (CIs)]) for colorectal, liver, lung, kidney, breast, and thyroid cancer were not significantly increased or decreased: 0.92 [0.61–1.38], 0.90 [0.53–1.53], 1.00 [0.73–1.37], 1.20 [0.62–2.34], 0.91 [0.62–1.34], and 0.91 [0.66–1.26], respectively. The increased risk of lymphoma in the infliximab user (2.49 [1.33–4.66]; <i>p</i> &lt; 0.01) was statistically significant. Similarly, the risk of leukemia increased significantly in the etanercept (3.87 [1.71–8.76]; <i>p</i> &lt; 0.01) and adalimumab (3.36 [1.65, 6.84]; <i>p</i> &lt; 0.001) user. Accumulated prescriptions of TNFi for two years did not increase the incidence of cancer, except lymphoma and leukemia. Since the use of TNFi increases the risk of leukemia and lymphoma, a decision for frequent prescription of TNF-α inhibitors should be more careful.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Risk of hematologic malignancies in psoriasis and rheumatoid arthritis patients using long term TNF-α inhibitors: a retrospective nationwide study

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年3月7日

查看全文
  • Jihun Song,
  • Seong Rae Kim,
  • Yu-Jin Kim,
  • Sun Jae Park,
  • Seogsong Jeong,
  • Sang Min Park

摘要

This retrospective cohort study included all user of tumor necrosis factor-α inhibitors (TNFi), including etanercept, infliximab, adalimumab, and golimumab, among Korean patients with psoriasis and rheumatoid arthritis (N of user = 7,645) and the non-user who was diagnosed with same diseases, never used TNFi, and was served as the reference. Cumulative usage of TNFi was calculated between the newly diagnosed date and index date (2-year from the diagnosed date). Adjusted hazard ratio (aHR [95% confidence intervals (CIs)]) for colorectal, liver, lung, kidney, breast, and thyroid cancer were not significantly increased or decreased: 0.92 [0.61–1.38], 0.90 [0.53–1.53], 1.00 [0.73–1.37], 1.20 [0.62–2.34], 0.91 [0.62–1.34], and 0.91 [0.66–1.26], respectively. The increased risk of lymphoma in the infliximab user (2.49 [1.33–4.66]; p < 0.01) was statistically significant. Similarly, the risk of leukemia increased significantly in the etanercept (3.87 [1.71–8.76]; p < 0.01) and adalimumab (3.36 [1.65, 6.84]; p < 0.001) user. Accumulated prescriptions of TNFi for two years did not increase the incidence of cancer, except lymphoma and leukemia. Since the use of TNFi increases the risk of leukemia and lymphoma, a decision for frequent prescription of TNF-α inhibitors should be more careful.