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<p>Shorter telomere length (TL) is associated with an increased risk for developing chronic or age-related diseases in adults. The process of telomere shortening is accelerated in response to stress and is well characterized in adult populations from high-income countries. Prior studies suggest the relationship between stress, shorter TL, and disease risk initiates in early life. Nested within the WASH Benefits Bangladesh trial, we examined associations between parental stressors, including maternal exposure to intimate partner violence (IPV), maternal depressive symptoms, and parental perceived stress, and child TL in rural Bangladesh. We measured whole blood relative TL in 660 children at median age 14 months and 702 children at median age 28 months. We estimated mean differences between the 25th and 75th percentile or absence and presence of each exposure using generalized additive models. IPV during pregnancy was associated with more TL attrition between 14 and 28 months (− 0.32 (95% CI − 0.64, − 0.01), p-value 0.05). This association was not significant after correction for multiple comparisons. Other parental psychosocial stressors were not associated with child TL outcomes at 14 or 28 months of age in rural Bangladesh. Telomere biology during early-life development may vary across settings.</p>

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Maternal experience of intimate partner violence, maternal depression, and parental stress are not associated with child telomere length in Bangladesh

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年3月12日

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  • Diego Figueroa,
  • Md. Mahfuz Al Mamun,
  • Da Kyung Jung,
  • Gaoge Li,
  • Sophia T. Tan,
  • Farheen Jamshed,
  • Zachary Butzin-Dozier,
  • Andrew N. Mertens,
  • Jue Lin,
  • Helen O. Pitchik,
  • Kausar Parvin,
  • Alexis Silvera,
  • Lia C. H. Fernald,
  • Benjamin F. Arnold,
  • Shahjahan Ali,
  • Abul K. Shoab,
  • Syeda Luthfa Famida,
  • Salma Akther,
  • Md. Ziaur Rahman,
  • Md. Saheen Hossen,
  • Palash Mutsuddi,
  • Mahbubur Rahman,
  • Leanne Unicomb,
  • Patricia Kariger,
  • Christine P. Stewart,
  • Alan E. Hubbard,
  • Jade Benjamin-Chung,
  • Firdaus S. Dhabhar,
  • Stephen P. Luby,
  • John M. Colford Jr.,
  • Ruchira Tabassum Naved,
  • Audrie Lin

摘要

Shorter telomere length (TL) is associated with an increased risk for developing chronic or age-related diseases in adults. The process of telomere shortening is accelerated in response to stress and is well characterized in adult populations from high-income countries. Prior studies suggest the relationship between stress, shorter TL, and disease risk initiates in early life. Nested within the WASH Benefits Bangladesh trial, we examined associations between parental stressors, including maternal exposure to intimate partner violence (IPV), maternal depressive symptoms, and parental perceived stress, and child TL in rural Bangladesh. We measured whole blood relative TL in 660 children at median age 14 months and 702 children at median age 28 months. We estimated mean differences between the 25th and 75th percentile or absence and presence of each exposure using generalized additive models. IPV during pregnancy was associated with more TL attrition between 14 and 28 months (− 0.32 (95% CI − 0.64, − 0.01), p-value 0.05). This association was not significant after correction for multiple comparisons. Other parental psychosocial stressors were not associated with child TL outcomes at 14 or 28 months of age in rural Bangladesh. Telomere biology during early-life development may vary across settings.