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<p>Excessive gestational weight gain may be associated with unfavorable pregnancy outcomes. We explored the impact of excessive weight gain on components of HDL metabolism in maternal plasma: sterol composition of HDL particles, distribution of HDL subclasses and <i>SCARB1</i>, <i>ABCA1</i> and <i>ABCG1</i> genes expressions and their associations with newborns’ characteristics. The study included 124 pregnant women, 58 with recommended and 66 with excessive weight gain. Concentrations of cholesterol synthesis marker, desmosterol, within HDL increased during pregnancy in both groups of participants. In women with excessive weight gain, levels of cholesterol absorption marker, campesterol, within HDL were significantly lower in the 3<sup>rd</sup> trimester compared to the 1<sup>st</sup> and 2<sup>nd</sup> trimesters. Relative proportions of large HDL 2b subclasses increased during pregnancy in women with recommended weight gain. Women with high pre-pregnancy BMI and excessive gestational weight gain had the lowest levels of β-sitosterol within HDL and the highest relative proportions of HDL 3a and HDL 3b subclasses in the 2<sup>nd</sup> trimester. Large HDL 2b particles were in positive correlation, while smaller HDL 3 subclasses and <i>SCARB1</i> gene expressions were in negative correlation with APGAR scores. In conclusion, excessive weight gain could contribute to altered metabolism of HDL, and subsequently to poorer neonatal outcomes.</p>

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Associations of excessive gestational weight gain with changes in components of maternal reverse cholesterol transport and neonatal outcomes

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年2月17日

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  • Minja Derikonjic,
  • Jelena Vekic,
  • Aleksandra Stefanovic,
  • Marija Saric Matutinovic,
  • Jelena Munjas,
  • Tamara Antonic,
  • Marija Mitrovic,
  • Daniela Ardalic,
  • Marko Stankovic,
  • Tamara Gojkovic,
  • Milica Miljkovic Trailovic,
  • Jasmina Ivanisevic,
  • Natasa Bogavac Stanojevic,
  • Snezana Jovicic,
  • Zeljko Mikovic,
  • Aleksandra Zeljkovic

摘要

Excessive gestational weight gain may be associated with unfavorable pregnancy outcomes. We explored the impact of excessive weight gain on components of HDL metabolism in maternal plasma: sterol composition of HDL particles, distribution of HDL subclasses and SCARB1, ABCA1 and ABCG1 genes expressions and their associations with newborns’ characteristics. The study included 124 pregnant women, 58 with recommended and 66 with excessive weight gain. Concentrations of cholesterol synthesis marker, desmosterol, within HDL increased during pregnancy in both groups of participants. In women with excessive weight gain, levels of cholesterol absorption marker, campesterol, within HDL were significantly lower in the 3rd trimester compared to the 1st and 2nd trimesters. Relative proportions of large HDL 2b subclasses increased during pregnancy in women with recommended weight gain. Women with high pre-pregnancy BMI and excessive gestational weight gain had the lowest levels of β-sitosterol within HDL and the highest relative proportions of HDL 3a and HDL 3b subclasses in the 2nd trimester. Large HDL 2b particles were in positive correlation, while smaller HDL 3 subclasses and SCARB1 gene expressions were in negative correlation with APGAR scores. In conclusion, excessive weight gain could contribute to altered metabolism of HDL, and subsequently to poorer neonatal outcomes.