<p>The purpose of this study was to compare the impact of modified heartpreservation techniques with conventional heart preservation techniques on hearttransplant recipients. The goal was to determine if these modified preservationtechniques could extend the preservation of the donor heart without increasing therisk of recipient mortality. A retrospective analysis was carried out on 763 casesof orthotopic heart transplantation performed at Wuhan Union Hospital and NanjingFirst Hospital, from September 2008 to October 2022. Among these, 656 casesunderwent modified heart preservation and were assigned to the study group, while107 cases underwent conventional heart preservation and were designated as thecontrol group. Detailed information from both groups was collected and compared,including demographic and donor characteristics, survival status, disease type, andrecipient/donor characteristics. The study revealed that the modified heartpreservation method did not increase the risk of mortality compared to theconventional method. However, it was found that patient factors such as diagnosticclassification, recipient age, and donor age significantly influenced mortality riskand were strongly associated with patient survival. The preservation time of thedonor heart was significantly longer in the study group compared to the controlgroup, without affecting the survival of the transplant recipients. The findings ofour study suggest that modified heart preservation techniques hold promise as apotential method for prolonging heart preservation time. Despite extending thepreservation period, these modified techniques did not increase the mortality riskin heart transplant recipients. This could potentially allow for more flexibility inthe long-distance transport and preservation of hearts, thereby broadening the scopeof viable donors for heart transplantation.</p>