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<p>Patients with traumatic spinal cord injury (SCI) frequently develop urinary tract infections (UTI) which may compromise neurological rehabilitation. We explored risk factors for UTI, including immunological biomarkers, in patients with acute traumatic SCI during the transition from acute to subacute phase. Two observational studies were analysed separately: a retrospective study (COaT-SCI, n = 296, follow-up 13&#xa0;weeks), and a prospective immunological study (SCIentinel, n = 70, follow-up 10&#xa0;weeks). Cox regression models were used to examine associations of first UTI with patient characteristics and longitudinal immunological parameters. Cumulative incidence of first UTI was approximately 50% at six weeks. Results indicated higher UTI risk in older patients and time-varying associations for SCI severity (ASIA impairment scale) and presence of accompanying injuries. Higher cellular immune competence, particularly CD8 + T-cell counts and higher IFN-γ/IL-4 ratio in functional T-cell assays, were associated with a lower UTI risk (HR [95% CI] per log-transformed unit: CD8 + T-cells 0.34 [0.18—0.65], IFN-γ/IL-4 ratio 0.53 [0.33–0.83]). Adding cellular immune markers improved models’ discriminative ability (weighted C-index at 21&#xa0;days from 0.68 to 0.76 with CD8 + T-cells). These findings indicate UTI is facilitated by systemic immune alterations, with T-cell parameters representing promising predictive biomarkers requiring further validation before clinical implementation.</p>

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T-cell biomarkers improve urinary tract infection risk stratification beyond clinical characteristics after acute traumatic spinal cord injury

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年1月10日

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  • Oliver Schweizerhof,
  • Christian Meisel,
  • Christian Blex,
  • Paolo Cinelli,
  • Ralf Watzlawick,
  • Tom Lübstorf,
  • Laura-Christin Geurtz,
  • Martin Kreutzträger,
  • Elias Baumgartner,
  • Julian Hirt,
  • Magdalena Hoppe,
  • Nadine Unterwalder,
  • Uwe Kölsch,
  • Ralf Böthig,
  • Burkhard Domurath,
  • Claudia Druschel,
  • Klaus-Dieter Schaser,
  • Andreas Niedeggen,
  • Armin Curt,
  • Michael G. Fehlings,
  • Peter Vajkoczy,
  • Axel Ekkernkamp,
  • Thomas Liebscher,
  • Jan M. Schwab,
  • Marcel A. Kopp,
  • Ulrike Grittner

摘要

Patients with traumatic spinal cord injury (SCI) frequently develop urinary tract infections (UTI) which may compromise neurological rehabilitation. We explored risk factors for UTI, including immunological biomarkers, in patients with acute traumatic SCI during the transition from acute to subacute phase. Two observational studies were analysed separately: a retrospective study (COaT-SCI, n = 296, follow-up 13 weeks), and a prospective immunological study (SCIentinel, n = 70, follow-up 10 weeks). Cox regression models were used to examine associations of first UTI with patient characteristics and longitudinal immunological parameters. Cumulative incidence of first UTI was approximately 50% at six weeks. Results indicated higher UTI risk in older patients and time-varying associations for SCI severity (ASIA impairment scale) and presence of accompanying injuries. Higher cellular immune competence, particularly CD8 + T-cell counts and higher IFN-γ/IL-4 ratio in functional T-cell assays, were associated with a lower UTI risk (HR [95% CI] per log-transformed unit: CD8 + T-cells 0.34 [0.18—0.65], IFN-γ/IL-4 ratio 0.53 [0.33–0.83]). Adding cellular immune markers improved models’ discriminative ability (weighted C-index at 21 days from 0.68 to 0.76 with CD8 + T-cells). These findings indicate UTI is facilitated by systemic immune alterations, with T-cell parameters representing promising predictive biomarkers requiring further validation before clinical implementation.