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<p><i>Klebsiella pneumoniae</i> is a gram-negative, opportunistic pathogen, with high rates of antimicrobial resistance, and is responsible for a wide range of infections of the urinary tract, lungs, and bloodstream, among others. Disease burden is particularly high in neonates, where <i>K. pneumoniae</i> is a leading cause of sepsis. Renewed interest in vaccine development against this critical priority pathogen has focused on this vulnerable population. Vaccination in pregnancy is a promising approach for prevention of neonatal sepsis, however efforts to understand the dynamics, specificity and function of maternally transferred antibodies is ongoing. We report here that <i>K. pneumoniae</i>-specific IgG is readily transferred from dam to pup following wild-type infection in mice, and that maternally-transferred immunity is protective against lethal infection in pups aged 6 weeks. Further work to investigate the mechanisms of protection and explore neonatal challenge models will advance the path to a maternal vaccine to protect against neonatal sepsis.</p>

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Transfer of anti-Klebsiella pneumoniae immunity following infection in mice is protective against lethal challenge in offspring

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年1月8日

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  • Emily Mason,
  • Kaitlin Winter,
  • Jiawei Liang,
  • Sina Hakimpour,
  • Rhienna Patel,
  • Tony Harn,
  • Ken H. Chu,
  • Hennady Shulha,
  • Bing Cai,
  • Mandy Lo,
  • Manish Sadarangani

摘要

Klebsiella pneumoniae is a gram-negative, opportunistic pathogen, with high rates of antimicrobial resistance, and is responsible for a wide range of infections of the urinary tract, lungs, and bloodstream, among others. Disease burden is particularly high in neonates, where K. pneumoniae is a leading cause of sepsis. Renewed interest in vaccine development against this critical priority pathogen has focused on this vulnerable population. Vaccination in pregnancy is a promising approach for prevention of neonatal sepsis, however efforts to understand the dynamics, specificity and function of maternally transferred antibodies is ongoing. We report here that K. pneumoniae-specific IgG is readily transferred from dam to pup following wild-type infection in mice, and that maternally-transferred immunity is protective against lethal infection in pups aged 6 weeks. Further work to investigate the mechanisms of protection and explore neonatal challenge models will advance the path to a maternal vaccine to protect against neonatal sepsis.