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<p>The knockout (KO) of the myostatin (MSTN) gene can increase muscle production in Mongolian cattle; however, the safety of MSTN-KO beef has not been evaluated. In this study, we fed mice varying concentrations of MSTN-KO beef and monitored physiological and tissue changes. Compared with the control group fed with wild-type beef, mice fed with MSTN-KO beef did not show significant changes, including weight gain, food intake, and organ weight. Furthermore, most blood parameters of the experimental groups remained stable. Serum metabolomics analysis confirmed that MSTN-KO beef had a limited impact on the mice’s overall metabolism, with only 24 differential metabolites identified. Our findings from this 90-day trial show no toxic effects of MSTN-KO Mongolian beef on mice. This directly addresses the long-standing lack of toxicity data for such gene-edited beef. Notably, this is the first study to fill the research gap, and the evidence generated in this work actively supports the safety assessment of MSTN-modified animal-derived foods.</p>

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A 90-day safety study of meat from MSTN gene-edited Mongolian cattle in mice

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年1月15日

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  • Jia-Hao Chen,
  • Hong-Yu Gong,
  • Zhao-Yu Wen,
  • De-Zheng Wang,
  • Tao Wang,
  • Li-Shuang Song,
  • Xue-Fei Liu,
  • Guang-Peng Li,
  • Chun-Ling Bai,
  • Lei Yang

摘要

The knockout (KO) of the myostatin (MSTN) gene can increase muscle production in Mongolian cattle; however, the safety of MSTN-KO beef has not been evaluated. In this study, we fed mice varying concentrations of MSTN-KO beef and monitored physiological and tissue changes. Compared with the control group fed with wild-type beef, mice fed with MSTN-KO beef did not show significant changes, including weight gain, food intake, and organ weight. Furthermore, most blood parameters of the experimental groups remained stable. Serum metabolomics analysis confirmed that MSTN-KO beef had a limited impact on the mice’s overall metabolism, with only 24 differential metabolites identified. Our findings from this 90-day trial show no toxic effects of MSTN-KO Mongolian beef on mice. This directly addresses the long-standing lack of toxicity data for such gene-edited beef. Notably, this is the first study to fill the research gap, and the evidence generated in this work actively supports the safety assessment of MSTN-modified animal-derived foods.