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<p>Oxidative stress and advanced glycation end products (AGEs) could promote vascular aging in type 2 diabetes mellitus (T2DM), but their relationship with glycemic variability remains unclear. We conducted a cross-sectional study of 68 patients with T2DM who underwent continuous glucose monitoring (CGM). Short-, intermediate-, and long-term glycemic variability were assessed using the % coefficient of variation of glucose (%CV), mean of daily differences (MODD), and HbA1c variability over the prior 2&#xa0;years, respectively. Oxidative stress was measured by the diacron-reactive oxygen metabolites (d-ROMs) test, and AGE accumulation by skin autofluorescence (SAF). Multivariate analyses identified female sex, %CV, MODD, and nephropathy stage as independent correlates of d-ROMs (adjusted R<sup>2</sup> = 0.436). Duration of diabetes, MODD, urinary albumin-to-creatinine ratio, and macroangiopathy were independently associated with SAF (adjusted R<sup>2</sup> = 0.265). This study suggests that short- and intermediate-term glycemic variability correlate with oxidative stress and AGE accumulation, which may be associated with vascular complications in T2DM.</p>

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Association of glycemic variability with oxidative stress and AGE accumulation in type 2 diabetes

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年12月11日

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  • Makoto Ohara,
  • Noriyuki Takahashi,
  • Nobuaki Takehana,
  • Naoya Osaka,
  • Hiroe Sugita,
  • Michishige Terasaki,
  • Yusaku Mori,
  • Tomoyasu Fukui,
  • Sho-ichi Yamagishi

摘要

Oxidative stress and advanced glycation end products (AGEs) could promote vascular aging in type 2 diabetes mellitus (T2DM), but their relationship with glycemic variability remains unclear. We conducted a cross-sectional study of 68 patients with T2DM who underwent continuous glucose monitoring (CGM). Short-, intermediate-, and long-term glycemic variability were assessed using the % coefficient of variation of glucose (%CV), mean of daily differences (MODD), and HbA1c variability over the prior 2 years, respectively. Oxidative stress was measured by the diacron-reactive oxygen metabolites (d-ROMs) test, and AGE accumulation by skin autofluorescence (SAF). Multivariate analyses identified female sex, %CV, MODD, and nephropathy stage as independent correlates of d-ROMs (adjusted R2 = 0.436). Duration of diabetes, MODD, urinary albumin-to-creatinine ratio, and macroangiopathy were independently associated with SAF (adjusted R2 = 0.265). This study suggests that short- and intermediate-term glycemic variability correlate with oxidative stress and AGE accumulation, which may be associated with vascular complications in T2DM.