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<p>Understanding the developmental trajectory of autism spectrum disorder (ASD) remains a critical barrier for timely intervention in children. Here, we investigated the deficit brain maturation trajectory during childhood development in 35 ASD level 1 and 35 neurotypical children through an electroencephalography (EEG) approach. An empirical study of the potential EEG biomarkers was demonstrated in a comprehensive view of group difference and age-related group comparison using alpha power, peak alpha frequency and transfer entropy during resting. We found a significant disruption of directional brain network communication between regions in children with ASD compared to neurotypical children. Our results also suggested that the children with ASD had altered occipital alpha power and peak alpha frequency development. The present study revealed promising findings that underpinned the developmental disruption of autism spectrum disorder, which may provide a prevailing insight into the disease pathology mechanisms, paving the way for future intervention advancement.</p>

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Autism spectrum disorder disrupts brain network connectivity maturation during childhood development

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年12月1日

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  • Lattika Tiawongsuwan,
  • Sumeth Klomchitcharoen,
  • Wachiraya Chumanee,
  • Tanchanok Tangwattanasirikun,
  • Soracha Saksittikorn,
  • Saharat Chawaruechai,
  • Tirapoot Jatupornpoonsub,
  • Yodchanan Wongsawat

摘要

Understanding the developmental trajectory of autism spectrum disorder (ASD) remains a critical barrier for timely intervention in children. Here, we investigated the deficit brain maturation trajectory during childhood development in 35 ASD level 1 and 35 neurotypical children through an electroencephalography (EEG) approach. An empirical study of the potential EEG biomarkers was demonstrated in a comprehensive view of group difference and age-related group comparison using alpha power, peak alpha frequency and transfer entropy during resting. We found a significant disruption of directional brain network communication between regions in children with ASD compared to neurotypical children. Our results also suggested that the children with ASD had altered occipital alpha power and peak alpha frequency development. The present study revealed promising findings that underpinned the developmental disruption of autism spectrum disorder, which may provide a prevailing insight into the disease pathology mechanisms, paving the way for future intervention advancement.