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<p>Tick-borne spotted fever group (SFG) rickettsioses are considered emerging vector-borne infectious diseases with potentially severe consequences for public health, particularly in the temperate regions of Europe. The aim of the study was to determine the prevalence and the diversity of <i>Rickettsia</i> spp. in questing <i>Ixodes ricinus</i> ticks in north-eastern Poland, evaluate the serological evidence of exposure to SFG rickettsiae among adult residents of this region, as well as to determine the level of SFG rickettsiae co-infection with <i>Borrelia</i> spirochaetes in ticks and humans. In a total of 4090 ticks, the presence of <i>Rickettsia</i> spp. was detected by PCR and confirmed by sequencing. IgG antibodies against SFG <i>Rickettsia</i> and <i>Borrelia</i> were detected using ELISA. Rickettsial DNA was revealed in 11.3% of females, 11.8% of males and nymphs of 6.5% (MIR, minimum infection rate). Based on DNA sequencing, <i>R. helvetica</i> and <i>R. monacensis</i> were identified. IgG antibodies against SFG rickettsiae were confirmed in 38.7% of adult residents of north-eastern Poland. The co-infection rate of SFG rickettsiae with <i>Borrelia</i> spirochaetes in questing adult <i>I. ricinus</i> ticks was low (2.6%), compared to the co-infection rate (16.1%) observed based on the presence of immunological responses in the study group of residents from northeastern Poland. These findings provide important evidence filling the gap between the environmental detection of SFG rickettsiae in vector populations and the limited number of diagnosed clinical cases in humans.</p>

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Molecular and serological evidence of spotted fever group rickettsiae and Borrelia co-infection in Ixodes ricinus and humans in north-eastern Poland

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年12月2日

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  • Katarzyna Kubiak,
  • Hanna Szymańska,
  • Sylwia Krzętowska,
  • Blanka Wolszczak-Biedrzycka,
  • Barbara Dolińska,
  • Marta Łukian,
  • Anna Bieńkowska,
  • Piotr Kocbach

摘要

Tick-borne spotted fever group (SFG) rickettsioses are considered emerging vector-borne infectious diseases with potentially severe consequences for public health, particularly in the temperate regions of Europe. The aim of the study was to determine the prevalence and the diversity of Rickettsia spp. in questing Ixodes ricinus ticks in north-eastern Poland, evaluate the serological evidence of exposure to SFG rickettsiae among adult residents of this region, as well as to determine the level of SFG rickettsiae co-infection with Borrelia spirochaetes in ticks and humans. In a total of 4090 ticks, the presence of Rickettsia spp. was detected by PCR and confirmed by sequencing. IgG antibodies against SFG Rickettsia and Borrelia were detected using ELISA. Rickettsial DNA was revealed in 11.3% of females, 11.8% of males and nymphs of 6.5% (MIR, minimum infection rate). Based on DNA sequencing, R. helvetica and R. monacensis were identified. IgG antibodies against SFG rickettsiae were confirmed in 38.7% of adult residents of north-eastern Poland. The co-infection rate of SFG rickettsiae with Borrelia spirochaetes in questing adult I. ricinus ticks was low (2.6%), compared to the co-infection rate (16.1%) observed based on the presence of immunological responses in the study group of residents from northeastern Poland. These findings provide important evidence filling the gap between the environmental detection of SFG rickettsiae in vector populations and the limited number of diagnosed clinical cases in humans.