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<p>Electrical impedance tomography (EIT)–guided positive end-expiratory pressure (PEEP) titration may optimize ventilation and reduce ventilator-induced lung injury in acute respiratory distress syndrome (ARDS). We compared EIT-guided PEEP with low PEEP/FiO₂ strategy in patients with moderate-to-severe ARDS. In this randomized controlled trial, 108 patients with PaO₂/FiO₂ below 200&#xa0;mmHg were allocated to EIT-guided PEEP after a recruitment maneuver (n = 56) or low PEEP/FiO₂ strategy (n = 52). Patients in the EIT group underwent PEEP titration guided by the intersection point between alveolar overdistension and collapse during a decremental PEEP trial. Primary outcomes were oxygenation (PaO₂/FiO₂) and static compliance. Secondary outcomes included mortality, ventilator-free days, ICU stay, barotrauma, rescue therapies, and sequential organ failure assessment (SOFA) score changes. On day 1, oxygenation was higher with EIT (mean PaO₂/FiO₂ 180 vs. 159&#xa0;mmHg; p = 0.036). Static compliance was greater at both day 1 (26 vs. 23&#xa0;mL/cmH₂O; p = 0.016) and day 2 (27 vs. 24&#xa0;mL/cmH₂O; p = 0.029). Driving pressure was lower with EIT at day 1 (16 vs. 17 cmH₂O; p &lt; 0.001) and day 2 (15 vs. 17 cmH₂O; p = 0.005). SOFA scores improved more in the EIT group (day 1: − 1 vs. 0, p = 0.013; day 2: − 1 vs. − 0.5, p = 0.015). Twenty-eight–day mortality was lower with EIT (29 vs. 44%), although not statistically significant (p = 0.090). ICU stay, ventilation duration, barotrauma, ECMO use, and rescue therapies were similar. Benefits were most pronounced in patients with severe ARDS. EIT-guided PEEP improved oxygenation, lung mechanics, and reduced organ dysfunction in moderate-to-severe ARDS, particularly in severe cases. It showed a trend toward reduced mortality and may serve as a practical bedside tool for lung-protective ventilation. Larger multicenter trials are needed to confirm its clinical benefits.</p><p>Trial registration: ClinicalTrials, NCT06733168. Registered on 13/12/2024, <a href="https://clinicaltrials.gov/study/NCT06733168">https://clinicaltrials.gov/study/NCT06733168</a>.</p>

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The impact of PEEP-guided electrical impedance tomography on oxygenation and respiratory mechanics in moderate-to-severe ARDS: a randomized controlled trial

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年11月29日

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  • Dinh Van Trung,
  • Bui Thi Huong Giang,
  • Dang Quoc Tuan,
  • Nguyen Cong Tan,
  • Pham The Thach,
  • Bui Van Cuong,
  • Nguyen Ba Cuong,
  • Trinh The Anh,
  • Nguyen Tu Anh,
  • Nguyen Van Huy,
  • Ho Duc Trieu,
  • Nguyen Van Trong,
  • Tran Thu Trang,
  • Vuong Xuan Toan,
  • Nguyen Hoang Nam,
  • Nguyen Thi Sam,
  • Truong Mau Thanh,
  • Nguyen Tien Dat,
  • Nghiem Thi Phuong Hong,
  • Pham Thi Hong Phuong,
  • Dang Duy Hien,
  • Do Van Hoi,
  • Hoang Tuan Phong,
  • Nguyen Dang Thu,
  • Nguyen Thao Trang,
  • Ngo Xuan Hieu,
  • Hoang Tien Dat,
  • Dao Xuan Phuong,
  • Do Ngoc Son

摘要

Electrical impedance tomography (EIT)–guided positive end-expiratory pressure (PEEP) titration may optimize ventilation and reduce ventilator-induced lung injury in acute respiratory distress syndrome (ARDS). We compared EIT-guided PEEP with low PEEP/FiO₂ strategy in patients with moderate-to-severe ARDS. In this randomized controlled trial, 108 patients with PaO₂/FiO₂ below 200 mmHg were allocated to EIT-guided PEEP after a recruitment maneuver (n = 56) or low PEEP/FiO₂ strategy (n = 52). Patients in the EIT group underwent PEEP titration guided by the intersection point between alveolar overdistension and collapse during a decremental PEEP trial. Primary outcomes were oxygenation (PaO₂/FiO₂) and static compliance. Secondary outcomes included mortality, ventilator-free days, ICU stay, barotrauma, rescue therapies, and sequential organ failure assessment (SOFA) score changes. On day 1, oxygenation was higher with EIT (mean PaO₂/FiO₂ 180 vs. 159 mmHg; p = 0.036). Static compliance was greater at both day 1 (26 vs. 23 mL/cmH₂O; p = 0.016) and day 2 (27 vs. 24 mL/cmH₂O; p = 0.029). Driving pressure was lower with EIT at day 1 (16 vs. 17 cmH₂O; p < 0.001) and day 2 (15 vs. 17 cmH₂O; p = 0.005). SOFA scores improved more in the EIT group (day 1: − 1 vs. 0, p = 0.013; day 2: − 1 vs. − 0.5, p = 0.015). Twenty-eight–day mortality was lower with EIT (29 vs. 44%), although not statistically significant (p = 0.090). ICU stay, ventilation duration, barotrauma, ECMO use, and rescue therapies were similar. Benefits were most pronounced in patients with severe ARDS. EIT-guided PEEP improved oxygenation, lung mechanics, and reduced organ dysfunction in moderate-to-severe ARDS, particularly in severe cases. It showed a trend toward reduced mortality and may serve as a practical bedside tool for lung-protective ventilation. Larger multicenter trials are needed to confirm its clinical benefits.

Trial registration: ClinicalTrials, NCT06733168. Registered on 13/12/2024, https://clinicaltrials.gov/study/NCT06733168.