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<p>Age-related hearing loss (ARHL) has a multifactorial pathogenesis, and the influence of alcohol consumption on it is controversial. This cross-sectional study investigated the association between ARHL and alcohol consumption by using cohort data from Tohoku Medical Megabank Project, including self-reported questionnaires and pure-tone audiometry thresholds (500, 1000, 2000, and 4000&#xa0;Hz). ARHL was defined as a threshold of &gt; 25&#xa0;dB in the better ear. Multiple logistic regression analyses (age 50–79 y; 5,219 men and 9,266 women) were conducted separately for men and women and indicated that daily alcohol consumption levels of 60–80 and ≥ 80&#xa0;g were significantly associated with increased odds of ARHL at 4,000&#xa0;Hz in men (odds ratio [OR] 1.42; 95% confidence interval [CI] 1.05–1.94; OR 1.55; 95% CI 1.12–2.16; respectively); consumption of 10–20&#xa0;g was significantly associated with reduced odds of ARHL at 4,000&#xa0;Hz in women (OR 0.81; 95% CI 0.68–0.96). Assessment of drinking-related single nucleotide polymorphisms suggested that the effect of alcohol on ARHL may differ by genotype. Our findings suggest a sex-specific association between alcohol consumption and ARHL; heavy drinking is a potential risk factor in men, whereas moderate drinking may have a protective effect in women.</p>

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Relationship between age-related hearing loss and alcohol consumption in a Japanese population

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年12月2日

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  • Hiyori Takahashi,
  • Jun Suzuki,
  • Ikuko N. Motoike,
  • Miyuki Sakurai,
  • Yuta Kobayashi,
  • Gosuke Watarai,
  • Hiroki Tozuka,
  • Mana Kogure,
  • Tetsuaki Kawase,
  • Yohei Honkura,
  • Ryoukichi Ikeda,
  • Kengo Kinoshita,
  • Naoki Nakaya,
  • Taku Obara,
  • Atsushi Hozawa,
  • Shinichi Kuriyama,
  • Nobuo Fuse,
  • Masayuki Yamamoto,
  • Yukio Katori

摘要

Age-related hearing loss (ARHL) has a multifactorial pathogenesis, and the influence of alcohol consumption on it is controversial. This cross-sectional study investigated the association between ARHL and alcohol consumption by using cohort data from Tohoku Medical Megabank Project, including self-reported questionnaires and pure-tone audiometry thresholds (500, 1000, 2000, and 4000 Hz). ARHL was defined as a threshold of > 25 dB in the better ear. Multiple logistic regression analyses (age 50–79 y; 5,219 men and 9,266 women) were conducted separately for men and women and indicated that daily alcohol consumption levels of 60–80 and ≥ 80 g were significantly associated with increased odds of ARHL at 4,000 Hz in men (odds ratio [OR] 1.42; 95% confidence interval [CI] 1.05–1.94; OR 1.55; 95% CI 1.12–2.16; respectively); consumption of 10–20 g was significantly associated with reduced odds of ARHL at 4,000 Hz in women (OR 0.81; 95% CI 0.68–0.96). Assessment of drinking-related single nucleotide polymorphisms suggested that the effect of alcohol on ARHL may differ by genotype. Our findings suggest a sex-specific association between alcohol consumption and ARHL; heavy drinking is a potential risk factor in men, whereas moderate drinking may have a protective effect in women.