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<p>This study investigates how puberty affects T-cell subpopulations in healthy individuals, aiming to understand why kidney transplant outcomes are worse during adolescence. We hypothesize that pubertal maturation shifts the immune system towards a more pro-inflammatory phenotype. To explore this, we examined T-cell subtypes in individuals aged 8–30y. Pubertal maturation was assessed in 66 healthy individuals (median age: 17y, 42% male) using skeletal age and Tanner stage, and individuals were subsequently classified into one of four pubertal stages (pre-: n = 10, early-: n = 8, late-: n = 6, and post-puberty: n = 42). Multiple differentiation stages of CD4, CD8, and TCRγδ T-cells subpopulations were determined in peripheral blood samples using flow cytometry. Our results showed that absolute naïve CD4 T-cell and recent thymic emigrant CD4 T-cell counts generally decreased over the course of puberty (<i>p</i> = 0.004, <i>p</i> = 0.015), while absolute CD4 effector memory cell counts increased (<i>p</i> = 0.002). Notably, higher absolute naïve CD4 T-cell counts were observed during early-puberty compared to post-puberty which could not be explained by aging (<i>p</i> = 0.19). These findings indicate a developmental shift during puberty from a naïve to a more mature T-cell profile, supporting the idea that pubertal maturation affects the composition of the immune system.</p>

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Pubertal stage specific changes in T-cell subpopulations in healthy individuals

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年12月8日

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  • Harm den Boer,
  • Anniek M. Terpstra,
  • Michiel G. H. Betjes,
  • Antonia H. M. Bouts,
  • Elisabeth A. M. Cornelissen,
  • Annemiek A. van der Eijk,
  • Daniëlle C. M. van der Kaay,
  • Karlijn M. E. Meys,
  • Edmond H. H. M. Rings,
  • Kim C. Heezen,
  • Huib de Jong,
  • Anton W. Langerak,
  • Femke H. M. Vrieling-Prince

摘要

This study investigates how puberty affects T-cell subpopulations in healthy individuals, aiming to understand why kidney transplant outcomes are worse during adolescence. We hypothesize that pubertal maturation shifts the immune system towards a more pro-inflammatory phenotype. To explore this, we examined T-cell subtypes in individuals aged 8–30y. Pubertal maturation was assessed in 66 healthy individuals (median age: 17y, 42% male) using skeletal age and Tanner stage, and individuals were subsequently classified into one of four pubertal stages (pre-: n = 10, early-: n = 8, late-: n = 6, and post-puberty: n = 42). Multiple differentiation stages of CD4, CD8, and TCRγδ T-cells subpopulations were determined in peripheral blood samples using flow cytometry. Our results showed that absolute naïve CD4 T-cell and recent thymic emigrant CD4 T-cell counts generally decreased over the course of puberty (p = 0.004, p = 0.015), while absolute CD4 effector memory cell counts increased (p = 0.002). Notably, higher absolute naïve CD4 T-cell counts were observed during early-puberty compared to post-puberty which could not be explained by aging (p = 0.19). These findings indicate a developmental shift during puberty from a naïve to a more mature T-cell profile, supporting the idea that pubertal maturation affects the composition of the immune system.