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<p>Annually, colorectal cancer (CRC) claims nearly 700,000 lives globally, thereby positioning it among the most lethal diseases worldwide. <i>Scutellaria barbata</i> D. Don (BZL), acknowledged for its demonstrated efficacy, is currently undergoing investigation as a potential therapeutic recourse for this formidable cancer. Seven diterpenes were tested, leading to identification of BZL-5 as the most promising compound. It exhibits activity against colorectal cancer via a number of different targets and mechanisms. Its ability to combat oxidative stress, inflammation, and apoptosis is believed to be the mechanism of action. With respect to BZL-5, HIF1A exhibits the highest binding affinity, and HIF-1 may be a crucial component in the pharmacological pathway. Experimental verification in vitro was explored the possible mechanism of BZL against colorectal cancer using a thorough analytical approach. The overarching objectives of this investigation are to demystify the underlying molecular mechanism and identify potential targets instrumental in the development of novel colorectal cancer therapeutics.</p>

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Mechanisms of diterpenes from Scutellaria Barbata D. Don against colorectal cancer via network pharmacology and experimental verification

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年11月28日

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  • Yuru Yang,
  • Xiaotian Cheng,
  • Yaonan He,
  • Tingting Chen,
  • Di Chen,
  • Andong Wang

摘要

Annually, colorectal cancer (CRC) claims nearly 700,000 lives globally, thereby positioning it among the most lethal diseases worldwide. Scutellaria barbata D. Don (BZL), acknowledged for its demonstrated efficacy, is currently undergoing investigation as a potential therapeutic recourse for this formidable cancer. Seven diterpenes were tested, leading to identification of BZL-5 as the most promising compound. It exhibits activity against colorectal cancer via a number of different targets and mechanisms. Its ability to combat oxidative stress, inflammation, and apoptosis is believed to be the mechanism of action. With respect to BZL-5, HIF1A exhibits the highest binding affinity, and HIF-1 may be a crucial component in the pharmacological pathway. Experimental verification in vitro was explored the possible mechanism of BZL against colorectal cancer using a thorough analytical approach. The overarching objectives of this investigation are to demystify the underlying molecular mechanism and identify potential targets instrumental in the development of novel colorectal cancer therapeutics.