<p>Personal protective tools, such as repellents, play a vital role in preventing mosquito-borne disease transmission. Although <i>N,N</i>-diethyl-meta-toluamide (DEET), a synthetic repellent, is effective against insects, it may cause allergic reactions. Therefore, there is a need to explore effective alternative repellents exhibiting fewer side effects. Here, we assessed the repellent activity of essential oils (EOs) from <i>Lippia multiflora</i> and <i>Cymbopogon citratus</i> alone and in combination, against <i>Anopheles</i> populations, using the Human Landing Catch (HLC) method in Dogona, Burkina Faso. For this purpose, five concentrations (0.5%, 1%, 1.5%, 2% and 2.5%) of each EO and their combination were applied on 68 volunteers legs from 6 p.m. to 9 a.m. on two consecutive nights. Also, DEET and ethanol were used as positive and negative controls respectively. As results, overall, houses with volunteers to whom EOs had been applied showed a reduction in the mean human biting rate (HBR), both indoors and outdoors (combination EO, 2.5%: 1.5 vs. control: 46.75 b h⁻¹&#xa0;n⁻¹). This combination exhibits an efficacy comparable to that of DEET (DEET: 2 b h⁻¹&#xa0;n⁻¹). This repellent effect is likely attributable to the dominant compounds present in the EOs namely, neral (44.7%) and geranial (55.2%) in <i>C. citratus</i>, and β-caryophyllene (20.1%), <i>p</i>-cymene (14.6%), and thymol acetate (12.0%) in <i>L. multiflora</i>. When the two essential oils were combined, they exhibited a synergistic repellent effect, resulting in a long protection time. The use of EOs as repellents may reduce the number of mosquito infectious bites/human/night, thereby contributing to a lower Entomological Inoculation Rate (EIR = 0.77). This study highlights the promising repellent potential of <i>C. citratus</i> and <i>L. multiflora</i> EOs, against wild mosquito populations.</p>