<p>Exploring the quality of life and factors affecting hospitalized pregnant and postpartum women with SARS-CoV-2 infection and thus providing a basis for improving the quality of health services. Hospitalized pregnant and postpartum women with SARS-CoV-2 infection in Suzhou City between October 2022 and December 2024 were taken as the study subjects, and questionnaires were administered to 512 patients using self-designed questionnaires and the EQ-5D scale. Univariate chi-square test, multivariate Logistic regression, and quantile regression analysis methods were used to analyze the quality of life and its influencing factors in hospitalized patients with SARS-CoV-2 infection. Of the five dimensions related to quality of life, the highest percentage of problems occurred with pain/discomfort (15.1%), followed by mobility impact (10.4%); median VAS score was 89. The results of multifactorial analysis showed that seven factors, including different stages of pregnancy, pre-pregnancy BMI, disease severity, and different stages of epidemic development, influenced the physical dimension-related EQ-5D; family income and disease severity had an effect on the psychological dimension-related EQ-5D. The education level and the presence of severe infection were identified as influencing factors for the 25th percentile of VAS scores, and being in the early stage of the epidemic and the presence of severe infection were influencing factors for the median VAS score. During the hospitalization of patients with SARS-CoV-2 infection, indicators of physical and psychological dimensions related to quality of life were affected to some extent, and as the epidemic progressed, the proportion of re-infected persons increased, and the impact on VAS scores decreased. Special attention should be paid to the fact that during the period of hospitalization, the indicators of psychological dimensions are influenced by the economic level of the family, in addition to the severity of the disease. </p>