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<p>Effects of seven antihypertensives of <i>Losartan Kalicum</i>(LK), <i>Atenolol</i>(ATEN), <i>Nifedipine</i>(NF), <i>Hydrochlorothiazide</i>(HCTZ), <i>Valsartan</i>(VLA), <i>Furosemide</i>(FUR<i>)</i> and <i>Captopril</i>(CAP) have been investigated on the degradation behavior of AZ31 alloy in simulated body fluid (Hank’s solution). LK, NF and HCTZ with the concentrations of 0.5, 1.0 and 0.5&#xa0;g/L can remarkably enhance the degradation resistance of AZ31 alloy by 63.1, 69.4 and 70.5%, respectively. The surface analysis reveals that the addition of LK, NF and HCTZ can reduce degradation rate by promoting the growth of hydroxyapatite, increasing the protection effect of corrosion film formed. The present results may enhance the corrosion resistance of Mg-based orthopedic implants.</p>

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Effects of antihypertensives on the degradation behavior of AZ31 alloy in in-vitro environment

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年11月20日

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  • Gang Xiao,
  • Min Fan,
  • Kui Wang,
  • Haonan Li,
  • Yazhao Shen,
  • Xufeng Cai,
  • Haiyan Jiang,
  • Guangling Wei,
  • Haiyan Yang

摘要

Effects of seven antihypertensives of Losartan Kalicum(LK), Atenolol(ATEN), Nifedipine(NF), Hydrochlorothiazide(HCTZ), Valsartan(VLA), Furosemide(FUR) and Captopril(CAP) have been investigated on the degradation behavior of AZ31 alloy in simulated body fluid (Hank’s solution). LK, NF and HCTZ with the concentrations of 0.5, 1.0 and 0.5 g/L can remarkably enhance the degradation resistance of AZ31 alloy by 63.1, 69.4 and 70.5%, respectively. The surface analysis reveals that the addition of LK, NF and HCTZ can reduce degradation rate by promoting the growth of hydroxyapatite, increasing the protection effect of corrosion film formed. The present results may enhance the corrosion resistance of Mg-based orthopedic implants.