Scholarlink

<p>Vertical sleeve gastrectomy (VSG) is the most performed metabolic bariatric surgery, and is known to improve fertility, leading to a rise in procedures among women of childbearing age. With an experimental model in Sprague–Dawley rats, we investigated the impact of pre-conceptional VSG on physiological functions of mothers, and its perinatal consequences during pregnancy. Female control rats (<i>Control</i>) received a standard diet, while others were fed a high-fat, high-sugar diet (HFHS). HFHS rats were divided into <i>Obese</i> and <i>Sleeve</i> groups. One month after surgery, all groups underwent gestation and subsequent lactation. Metabolic, cardiovascular and hepatic functions were evaluated 4&#xa0;months after VSG. From one-month post-surgery, <i>Sleeve</i> mothers showed decreased leptin and insulin levels compared to <i>Obese</i> mothers, normal fertility with similar litter size to <i>Control</i>, without any effect on birth weight of pups Three months later, although body weight and white adipose tissue were also normalized, <i>Sleeve</i> mothers exhibited a high level of hepatic fibrosis and a hypertrophic remodelling of the thoracic aorta. In addition, we detected an endothelial dysfunction of mesenteric arteries, with a stronger involvement of COX/PGI2 pathway in the vasoreactivity. While VSG improves metabolic function at short and middle term after surgery, our results highlight an alteration of hepatic and vascular functions which could lead to cardiovascular diseases.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Impact of preconceptional vertical sleeve gastrectomy on metabolic, cardiovascular and hepatic functions of Sprague Dawley female rats and perinatal consequences

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年11月7日

查看全文
  • Cyrielle Payen,
  • Abigaëlle Guillot,
  • Julien Chaigneau,
  • Lucile Bichot,
  • Eugénie Testa,
  • Jennifer Bourreau,
  • Géraldine Gascoin,
  • Emilie Vessières,
  • Coralyne Proux,
  • Valérie Moal,
  • Laurent Loufrani,
  • Françoise Schmitt,
  • Céline Fassot

摘要

Vertical sleeve gastrectomy (VSG) is the most performed metabolic bariatric surgery, and is known to improve fertility, leading to a rise in procedures among women of childbearing age. With an experimental model in Sprague–Dawley rats, we investigated the impact of pre-conceptional VSG on physiological functions of mothers, and its perinatal consequences during pregnancy. Female control rats (Control) received a standard diet, while others were fed a high-fat, high-sugar diet (HFHS). HFHS rats were divided into Obese and Sleeve groups. One month after surgery, all groups underwent gestation and subsequent lactation. Metabolic, cardiovascular and hepatic functions were evaluated 4 months after VSG. From one-month post-surgery, Sleeve mothers showed decreased leptin and insulin levels compared to Obese mothers, normal fertility with similar litter size to Control, without any effect on birth weight of pups Three months later, although body weight and white adipose tissue were also normalized, Sleeve mothers exhibited a high level of hepatic fibrosis and a hypertrophic remodelling of the thoracic aorta. In addition, we detected an endothelial dysfunction of mesenteric arteries, with a stronger involvement of COX/PGI2 pathway in the vasoreactivity. While VSG improves metabolic function at short and middle term after surgery, our results highlight an alteration of hepatic and vascular functions which could lead to cardiovascular diseases.