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<p>The global rise of antimicrobial resistance (AMR) poses a severe threat to public health, with multidrug-resistant pathogens undermining the efficacy of conventional antibiotics. Silver nanoparticles (AgNPs) have emerged as promising broad-spectrum antimicrobial agents. Here, we report a gamma radiation-assisted green synthesis of polyvinylpyrrolidone (PVP) or polyvinyl alcohol (PVA)-stabilized AgNPs, enabling rapid, sterile production of highly pure, uniformly dispersed nanoparticles without toxic byproducts, adapted for biomedical applications. Notably, AgNPs derived from Ag<sub>2</sub>SO<sub>4</sub> precursor exhibited superior optical properties, and smaller homogeneous particle sizes compared to those from conventional AgNO<sub>3</sub>. Optimized PVP-AgNPs demonstrated a well-known surface plasmon resonance near 396&#xa0;nm, with sizes in the range of 5–25&#xa0;nm as observed by transmission electron microscope, and a hydrodynamic diameter of ~ 33&#xa0;nm. The physicochemical characterization of AgNPs was performed via different techniques such as X-ray photoelectron spectroscopy and powder X-ray diffraction. Importantly, PVP-/PVA-AgNPs displayed potent antibacterial activity, with minimum inhibitory concentrations of ~ 1 and 1–2&#xa0;mg/L against <i>Staphylococcus aureus</i>, respectively, and 0.5&#xa0;mg/L against <i>Pseudomonas aeruginosa</i> and <i>Escherichia coli</i>. These findings highlight the potential of green, radiation-synthesized AgNPs as a promising platform for next-generation antimicrobial materials in medical applications.</p>

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Radiation-induced synthesis of silver nanocomposites and their antibacterial applications

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年11月18日

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  • Wenbo Liu,
  • Dominique Fourmy,
  • Diana Dragoe,
  • Hynd Remita,
  • Ruxandra Gref

摘要

The global rise of antimicrobial resistance (AMR) poses a severe threat to public health, with multidrug-resistant pathogens undermining the efficacy of conventional antibiotics. Silver nanoparticles (AgNPs) have emerged as promising broad-spectrum antimicrobial agents. Here, we report a gamma radiation-assisted green synthesis of polyvinylpyrrolidone (PVP) or polyvinyl alcohol (PVA)-stabilized AgNPs, enabling rapid, sterile production of highly pure, uniformly dispersed nanoparticles without toxic byproducts, adapted for biomedical applications. Notably, AgNPs derived from Ag2SO4 precursor exhibited superior optical properties, and smaller homogeneous particle sizes compared to those from conventional AgNO3. Optimized PVP-AgNPs demonstrated a well-known surface plasmon resonance near 396 nm, with sizes in the range of 5–25 nm as observed by transmission electron microscope, and a hydrodynamic diameter of ~ 33 nm. The physicochemical characterization of AgNPs was performed via different techniques such as X-ray photoelectron spectroscopy and powder X-ray diffraction. Importantly, PVP-/PVA-AgNPs displayed potent antibacterial activity, with minimum inhibitory concentrations of ~ 1 and 1–2 mg/L against Staphylococcus aureus, respectively, and 0.5 mg/L against Pseudomonas aeruginosa and Escherichia coli. These findings highlight the potential of green, radiation-synthesized AgNPs as a promising platform for next-generation antimicrobial materials in medical applications.