Scholarlink

<p>Nectin-4/PVRL-4 is overexpressed in tumors, driving proliferation and invasion. It’s a key target for solid tumor therapy. Current tumor imaging methods are inadequate. Studying nectin-4 in lung cancer helps identify diagnostic biomarkers and develop radionuclide probes, intraoperative visualization,and new chemotherapies. High nectin-4 expression in lung cancer tissues was confirmed using TCGA data and IHC. Three optical probes targeting nectin-4 were synthesized. Optimal binding conditions were explored, and binding rates were assessed. Animal experiments showed the probes’ specificity and biodistribution. The probes effectively targeted nectin-4, with Cy5.5-nectin-4 PEP 02 showing the highest binding rate. In vivo, the probe targeted lung cancer tissues, indicating potential for intraoperative navigation. Nectin-4 is a promising target for lung cancer and intraoperative navigation, guiding further research.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Synthesis of a novel specific nectin-4 tumor-targeted peptide optical molecular probe and its preliminary study in lung cancer

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年11月17日

查看全文
  • Ting Jiang,
  • Ke Dong,
  • Jianfei Fu,
  • Yong Zheng,
  • Bilian Zhu,
  • Qianqian Zhang,
  • Binjing Jiang,
  • Zhijian Zheng,
  • Mengjie Dong

摘要

Nectin-4/PVRL-4 is overexpressed in tumors, driving proliferation and invasion. It’s a key target for solid tumor therapy. Current tumor imaging methods are inadequate. Studying nectin-4 in lung cancer helps identify diagnostic biomarkers and develop radionuclide probes, intraoperative visualization,and new chemotherapies. High nectin-4 expression in lung cancer tissues was confirmed using TCGA data and IHC. Three optical probes targeting nectin-4 were synthesized. Optimal binding conditions were explored, and binding rates were assessed. Animal experiments showed the probes’ specificity and biodistribution. The probes effectively targeted nectin-4, with Cy5.5-nectin-4 PEP 02 showing the highest binding rate. In vivo, the probe targeted lung cancer tissues, indicating potential for intraoperative navigation. Nectin-4 is a promising target for lung cancer and intraoperative navigation, guiding further research.