<p>The purpose of this study is to describe the synthesis of typical porous metal-organic framework (MOF) materials based on nickel 2,6-pyridinedicarboxylic acid (Ni-MOF). Also, using a simple in-situ solvothermal method, CoFe₂O₄/nickel 2,6-Pyridinedicarboxylic acid (CoFe₂O₄/Ni-MOF) was synthesized as a magnetic MOF composite. The CoFe₂O₄/Ni-MOF and Ni-MOF were characterized by powder X-ray diffraction (XRD), field emission scanning electron microscopy (FE-SEM), energy-dispersive X-ray spectrometer (EDS), vibrating-sample magnetometer (VSM), Fourier transform infrared spectroscopy (FTIR), and nitrogen adsorption − desorption isotherm to confirm successful integration and its porous, and magnetic nature. The potential of Ni-MOF and CoFe₂O₄/Ni-MOF as catalysts was investigated for the one-pot synthesis of a diverse array of pharmaceutically active 5-substituted 1<i>H</i>-tetrazole derivatives. To optimize the reaction conditions, the efficiency of catalyst amounts, various solvents, and different temperatures has been studied using benzonitrile (1 mmol), a catalyst, and NaN₃ (1.2 mmol) as a model reaction. The developed material demonstrated remarkable efficiency (80%) in the synthesis of 5-(phenyl)-1<i>H</i>-tetrazole. An important aspect of this strategy is that it adheres to ecologically favorable reaction conditions (The reactions are based on green chemistry under mild reaction conditions in H₂O/EtOH solvent, at a relatively low temperature compared to the reported work). The CoFe₂O₄/Ni-MOF composite significantly outperformed the pure Ni-MOF, achieving an 80% yield in 20&#xa0;min versus 40&#xa0;min for the Ni-MOF, using the same catalyst mass (80&#xa0;mg) in H₂O /EtOH (1:1) solvent. The research demonstrates the deliberate design of a high-performance, retrievable magnetic MOF catalyst for sustainable organic synthesis.</p>