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<p>This study elucidates a novel Co<sup>2+</sup> ion fluorescence chemosensor 6-bromo-3-(2-(2-(4-nitrophenyl)-4,5-diphenyl-1<i>H</i>-imidazol-1-yl)thiazol-4-yl)-2<i>H</i>-chromen-2-one (NIC), which integrates imidazole and coumarin-thiazole moiety evolved over other frequently occurring metal ions. Fluorescence spectra are specifically used to study the complexation of NIC with different metal ions in an acetonotrile: water mixture (8:2) at room temperature. When Co<sup>2+</sup> was present, NIC shows a notable quenching of fluorescence at 450&#xa0;nm as a result of a complex forming which was accompanied by the emergence of a new band at 515&#xa0;nm in the uv visible spectrum. Also, the colour of NIC was changed from yellow to brown which was evident from naked eyes. The sensor NIC demonstrated its high sensitivity towards Co<sup>2+</sup> ions with a limit of detection (LOD) of 7 µM. The Job’s plot validates the 1:1 binding stoichiometry between Co<sup>2+</sup> and NIC. The chemosensor NIC also exhibited colorimetric and fluorometric sensing ability with a visible colorimetric response to Trifluoroacetic acid (TFA). Further, the study was also validated with zebrafish bioimaging studies.</p>

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Protan triggered colorimetric and fluorometric responsive coumarin coupled imidazole as Co2+ sensor, DFT and zebrafish bioimaging studies

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年11月4日

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  • Aravind R. Nesaragi,
  • Jyoti Nagalik,
  • Sharanappa Chapi,
  • Sharanakumar T. M.,
  • Venuprasad K. D.,
  • Naveen Kumar Kalagatur,
  • Sudhakar Poda,
  • Sanjeev R. Inamdar,
  • Shivarudrappa H. P.,
  • Rafa Almeer

摘要

This study elucidates a novel Co2+ ion fluorescence chemosensor 6-bromo-3-(2-(2-(4-nitrophenyl)-4,5-diphenyl-1H-imidazol-1-yl)thiazol-4-yl)-2H-chromen-2-one (NIC), which integrates imidazole and coumarin-thiazole moiety evolved over other frequently occurring metal ions. Fluorescence spectra are specifically used to study the complexation of NIC with different metal ions in an acetonotrile: water mixture (8:2) at room temperature. When Co2+ was present, NIC shows a notable quenching of fluorescence at 450 nm as a result of a complex forming which was accompanied by the emergence of a new band at 515 nm in the uv visible spectrum. Also, the colour of NIC was changed from yellow to brown which was evident from naked eyes. The sensor NIC demonstrated its high sensitivity towards Co2+ ions with a limit of detection (LOD) of 7 µM. The Job’s plot validates the 1:1 binding stoichiometry between Co2+ and NIC. The chemosensor NIC also exhibited colorimetric and fluorometric sensing ability with a visible colorimetric response to Trifluoroacetic acid (TFA). Further, the study was also validated with zebrafish bioimaging studies.