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<p>Lung diseases such as chronic obstructive pulmonary disease are a major health burden to society for which early detection plays a crucial role for treatment success. For detection, as well as diagnosis and serial evaluation, imaging plays a major role, but lung diseases are often still diagnosed in progressed states for which effective causal therapies do not presently exist. Recently, dark-field lung imaging has been introduced as a promising technique for early stage detection of alterations in lung micro-structures. This work presents an analyzer-free, full-scale lung imaging system based on a dual-phase interferometer, which allows tuning and direct resolution of grating induced intensity fringes. It provides the classical absorption chest image with additional dark-field information without significant attenuation of the patient-exposed photon-flux or the cost of large area absorption gratings. The detailed system achieves a dark-field sensitivity adequate for lung imaging, governed by system autocorrelation lengths of up to 0.6&#xa0;<InlineEquation ID="IEq1"> <InlineMediaObject> <ImageObject Color="BlackWhite" FileRef="41598_2025_22355_Article_IEq1.gif" Format="GIF" Height="13" Rendition="HTML" Resolution="72" Type="Linedraw" Width="26" /> </InlineMediaObject> <EquationSource Format="TEX">\({\upmu {\textrm{m}}}\)</EquationSource> </InlineEquation>. The computed tomography (CT) reconstructions show further evidence of the emergence of the dark-field in the parenchyma.</p>

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Synchrotron radiation based analyzer-free dual-phase dark-field lung imaging approach for radiography and CT

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年11月4日

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  • Simon Spindler,
  • Alexandre Pereira,
  • Caori Organista,
  • Marie-Christine Zdora,
  • Goran Lovric,
  • Ginevra Lautizi,
  • Christian Dullin,
  • Adriano Contillo,
  • Elena Longo,
  • Nicola Sodini,
  • Lorenzo D’Amico,
  • Lucia Romano,
  • Konstantins Jefimovs,
  • Daniel Josell,
  • Michał Rawlik,
  • Giuliana Tromba,
  • Marco Stampanoni

摘要

Lung diseases such as chronic obstructive pulmonary disease are a major health burden to society for which early detection plays a crucial role for treatment success. For detection, as well as diagnosis and serial evaluation, imaging plays a major role, but lung diseases are often still diagnosed in progressed states for which effective causal therapies do not presently exist. Recently, dark-field lung imaging has been introduced as a promising technique for early stage detection of alterations in lung micro-structures. This work presents an analyzer-free, full-scale lung imaging system based on a dual-phase interferometer, which allows tuning and direct resolution of grating induced intensity fringes. It provides the classical absorption chest image with additional dark-field information without significant attenuation of the patient-exposed photon-flux or the cost of large area absorption gratings. The detailed system achieves a dark-field sensitivity adequate for lung imaging, governed by system autocorrelation lengths of up to 0.6  \({\upmu {\textrm{m}}}\) . The computed tomography (CT) reconstructions show further evidence of the emergence of the dark-field in the parenchyma.