Scholarlink

<p>CD24 can bind to its receptor, Siglec-10, and suppress immune responses induced by tissue damage. We aimed to study serum biomarkers in CD24/Siglec-10 axis and explore their associations with the survival and neurological prognosis of patients after return of spontaneous circulation (ROSC) following cardiac arrest. A prospective cohort study was performed. Eligible patients with ROSC were enrolled. Clinical information and serum levels of sCD24, sSiglec-10, sialic acid, tumor necrosis factor (TNF-α), interleukin-6 (IL-6), high mobility group protein 1 (HMGB1), neuron specific enolase (NSE), and neuraminidase activity were collected on days 1, 3 and 7 after ROSC. The 28-day survival and neurological outcome were documented. The study included 104 ROSC patients, with 30 and 74 in survivor and non-survivor groups, respectively. The levels of all biomarkers, except for sSiglec-10, sialic acid, and neuraminidases on day 1, were significantly higher in non-survivor than survivor group. Serum sCD24 level was positively correlated with sialic acid, HMGB1, TNF-α, IL-6, NSE, neuraminidases activity, and APACHE II score. Multivariate logistic regression analysis showed that serum sCD24 level was independently associated with 28-day poor neurological prognosis and mortality after ROSC. Multiple serum biomarkers within the CD24/Siglec-10 axis were significantly elevated following ROSC. Elevated serum sCD24 level emerged as a predictor of both 28-day poor neurological prognosis and all-cause mortality in patients after cardiac arrest. Further large-scale studies are warranted to validate these findings.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Circulating CD24/Siglec-10 biomarkers predict post-resuscitation outcomes in a cardiac arrest cohort

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年10月29日

查看全文
  • Ying Liu,
  • Yushu Chen,
  • Ling Wang,
  • Dongping Yu,
  • Peiyan Chen,
  • Shaolin Chen,
  • Ping Gong

摘要

CD24 can bind to its receptor, Siglec-10, and suppress immune responses induced by tissue damage. We aimed to study serum biomarkers in CD24/Siglec-10 axis and explore their associations with the survival and neurological prognosis of patients after return of spontaneous circulation (ROSC) following cardiac arrest. A prospective cohort study was performed. Eligible patients with ROSC were enrolled. Clinical information and serum levels of sCD24, sSiglec-10, sialic acid, tumor necrosis factor (TNF-α), interleukin-6 (IL-6), high mobility group protein 1 (HMGB1), neuron specific enolase (NSE), and neuraminidase activity were collected on days 1, 3 and 7 after ROSC. The 28-day survival and neurological outcome were documented. The study included 104 ROSC patients, with 30 and 74 in survivor and non-survivor groups, respectively. The levels of all biomarkers, except for sSiglec-10, sialic acid, and neuraminidases on day 1, were significantly higher in non-survivor than survivor group. Serum sCD24 level was positively correlated with sialic acid, HMGB1, TNF-α, IL-6, NSE, neuraminidases activity, and APACHE II score. Multivariate logistic regression analysis showed that serum sCD24 level was independently associated with 28-day poor neurological prognosis and mortality after ROSC. Multiple serum biomarkers within the CD24/Siglec-10 axis were significantly elevated following ROSC. Elevated serum sCD24 level emerged as a predictor of both 28-day poor neurological prognosis and all-cause mortality in patients after cardiac arrest. Further large-scale studies are warranted to validate these findings.