Scholarlink

<p>Doxorubicin (DOX), a potent anticancer drug, requires sensitive and precise detection due to its narrow therapeutic window. In this study, a novel electrochemical sensor was developed by electrodepositing silver nanoprisms (AgNPrs), Fe<sub>3</sub>O<sub>4</sub> nanoparticles, and reduced graphene oxide aerogel (rGOA) on a glassy carbon electrode (GCE). The cyclic voltammetry technique was utilized for electrodeposition of Fe<sub>3</sub>O<sub>4</sub>@rGOA/AgNPrs nanocomposite within a potential range of − 1.0 to + 1.0&#xa0;V. The Fe<sub>3</sub>O<sub>4</sub>@rGOA/AgNPrs–modified GCE probe was optimized for the detection and quantification of DOX in human plasma samples. At an optimized pH of 6, DOX exhibited distinct redox behavior on the modified electrode. Differential pulse voltammetry was employed for the quantification of DOX and showed a wide linear dynamic range (0.075 to 5.0&#xa0;µg/mL) with a low limit of quantification (LLOQ) of 0.075&#xa0;µg/mL and limit of detection (LOD) of 0.028&#xa0;µg/mL in blood plasma. The developed sensor demonstrated excellent sensitivity, selectivity, and reproducibility, enabling direct quantification of DOX in plasma samples. These findings underscore the potential of the proposed sensor as a reliable, efficient, and cost-effective platform for therapeutic drug monitoring and clinical diagnostics.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Magnetic reduced graphene oxide aerogel decorated silver nanoparticles towards efficient recognition of doxorubicin in patients’ blood plasma

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年10月28日

查看全文
  • Hadi Gheybalizadeh,
  • Mina Goli,
  • Mohammad Hasanzadeh,
  • Yosra Vaez-Gharamaleki,
  • Abolghasem Jouyban,
  • Jafar Soleymani

摘要

Doxorubicin (DOX), a potent anticancer drug, requires sensitive and precise detection due to its narrow therapeutic window. In this study, a novel electrochemical sensor was developed by electrodepositing silver nanoprisms (AgNPrs), Fe3O4 nanoparticles, and reduced graphene oxide aerogel (rGOA) on a glassy carbon electrode (GCE). The cyclic voltammetry technique was utilized for electrodeposition of Fe3O4@rGOA/AgNPrs nanocomposite within a potential range of − 1.0 to + 1.0 V. The Fe3O4@rGOA/AgNPrs–modified GCE probe was optimized for the detection and quantification of DOX in human plasma samples. At an optimized pH of 6, DOX exhibited distinct redox behavior on the modified electrode. Differential pulse voltammetry was employed for the quantification of DOX and showed a wide linear dynamic range (0.075 to 5.0 µg/mL) with a low limit of quantification (LLOQ) of 0.075 µg/mL and limit of detection (LOD) of 0.028 µg/mL in blood plasma. The developed sensor demonstrated excellent sensitivity, selectivity, and reproducibility, enabling direct quantification of DOX in plasma samples. These findings underscore the potential of the proposed sensor as a reliable, efficient, and cost-effective platform for therapeutic drug monitoring and clinical diagnostics.